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Abdulrab Ahmed M. Alkhanjaf Md Tanwir Athar Zabih Ullah Abdullah Mohammed H. Alsayhab Ahmad Umar Ibrahim Ahmed Shaikh 《Molecules (Basel, Switzerland)》2022,27(23)
Doxorubicin (DOXO) is an antineoplastic drug that is used extensively in managing multiple cancer types. However, DOXO-induced cardiotoxicity is a limiting factor for its widespread use and considerably affects patients’ quality of life. Farnesol (FSN) is a sesquiterpene with antioxidant, anti-inflammatory, and anti-tumor properties. Thus, the current study explored the cardioprotective effect of FSN against DOXO-induced cardiotoxicity. In this study, male Wistar rats were randomly divided into five groups (n = 7) and treated for 14 days. Group I (Control): normal saline, p.o. daily for 14 days; Group II (TOXIC): DOXO 2.4 mg/kg, i.p, thrice weekly for 14 days; Group III: FSN 100 mg/kg, p.o. daily for 14 days + DOXO similar to Group II; Group IV: FSN 200 mg/kg, p.o. daily for 14 days + DOXO similar to Group II; Group V (Standard): nifedipine 10 mg/kg, p.o. daily for 14 days + DOXO similar to Group II. At the end of the study, animals were weighed, blood was collected, and heart-weight was measured. The cardiac tissue was used to estimate biochemical markers and for histopathological studies. The observed results revealed that the FSN-treated group rats showed decrease in heart weight and heart weight/body weight ratio, reversed the oxidative stress, cardiac-specific injury markers, proinflammatory and proapoptotic markers and histopathological aberrations towards normal, and showed cardioprotection. In summary, the FSN reduces cardiac injuries caused by DOXO via its antioxidant, anti-inflammatory, and anti-apoptotic potential. However, more detailed mechanism-based studies are needed to bring this drug into clinical use. 相似文献
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Yasmin Khan Md Tanwir Akhtar Romana Shehl Athar Ali Khan 《Journal of Applied Analysis & Computation》2015,5(1):38-51
Data generated in forestry biometrics are not normal in statistical sense as they rarely follow the normal regression model. Hence, there is a need to develop models and methods in forest biometric applications for non-normal models. Due to generality of Bayesian methods it can be implemented in the situations when Gaussian regression models do not fit the data. Data on diameter at breast height (dbh), which is a very important characteristic in forestry has been fitted to Weibull and gamma models in Bayesian paradigm and comparisons have also been made with its classical counterpart. It may be noted that MCMC simulation tools are used in this study. An attempt has been made to apply Bayesian simulation tools using \textbf{R} software. 相似文献
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Rafia Azmat Faryal Vali Mohammed Tehseen Ahmed Qurat-ul-Ain Tanwir 《Frontiers of Chemistry in China》2011,6(2):84-90
This article describes the potential of KMnO4 for oxidation of the thiazine dye (Toluidine blue TB) in an acidic medium. The effect of different operational parameters
like initial concentration of dye, potassium permanganate, pH, ionic strength, catalyst, acids and temperature were investigated
spectrophotometrically at λ
max = 613 nm. The results showed a complete removal of the TB with mineralization of the dye solution. Smooth and complete decoloration
was observed in the presence of monobasic acid (HCl) as compared to the H2SO4 where little color removal was observed. Pb was found to be an effective catalyst in oxidation for complete and fast decolorization
with mineralization. No significant change at elevated temperatures showed that an intermediate complex degraded with slight
change in the temperature. UV/visible spectrophotometry and GC mass analysis showed an intermediate activated complex demethylated
sulophooxide of TB which later on degraded into smaller fragments. 相似文献
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