An efficient green synthesis and antibacterial activity of 1,3-benzoxazine and 1,3-naphthoxazine using NaCl.SiO2 as solid catalyst in neat condition

A series of 1,3-oxazine derivatives were synthesized by a one-pot three-component (ie, phenol, formaldehyde, amine) method where SiO₂ bonded with NaCl was used as a reusable, more efficient, easily prepared, and available solid catalyst. The reactions were also carried out at room temperature for greener approach. in vitro studies for the synthesized compounds were also done against two gram-positive (Bacillus subtilis and Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Klebsiella pneumonia) to check for their applicability as an antibacterial agent where some of the synthesized compounds gives the best antibacterial activity against selected bacterial strains. Streptomycin was used as a standard control for all the microbial test.