Synthesis and Antimicrobial Activity of Amido Sulfonamido Methane Linked Bisoxazoles,Bisthiazoles, and Bisimidazoles

A new class of amido sulfonamido methane linked bisoxazoles, bisthiazoles, and bisimidazoles were prepared adopting simple and versatile synthetic methodologies. The lead compounds were assayed for antimicrobial activity.     

Effect of Solvents and pH on <Emphasis Type="Italic">β</Emphasis>-Cyclodextrin Inclusion Complexation of 2,4-Dihydroxyazobenzene and 4-Hydroxyazobenzene

The spectral characteristics of 2,4-dihydroxyazobenzene (DHAB, sudan orange G) and 4-hydroxyazobenzene (HAB) have been studied in various solvents, different hydrogen ion and β-cyclodextrin (β-CD) concentrations, and are compared with azobenzene (AB). The inclusion complexes of the above molecules with β-CD were analyzed by UV-vis spectrometry, flourometry, FT-IR, ¹H NMR, SEM and DFT methods. The solvent study shows that only the azo form is present in DHAB and HAB molecules. The unusually large red shift observed in acidic solutions indicates both molecules exhibit azo-hydrazo tautomerization. In the β-CD solutions, the increase in fluorescence intensity and large bathochromic shift in the S₁ state indicates that DHAB and HAB form 2:2 inclusion complexes, whereas AB forms a 1:1 inclusion complex.     

Synthesis of a New Class of Arylsulfonylethylsulfonylmethyloxazolines and Thiazolines

A new class of arylsulfonylethylsulfonylmethyl oxazolines and thiazolines were prepared using multistep, one‐pot methodologies exploiting lanthanide alkoxides and under microwave irradiation. The microwave method provides an excellent approach in a single step with high yields.     

Polarized Ketene Dithioacetals‐Versatile Synthons for Different Heterocycles

The reactivity of polarized ketene dithioacetals to develop a variety of heterocycles under different conditions was studied.     

Synthesis of a New Class of Sulfone Linked Bisheterocycles

A new class of sulfone linked bisheterocycles—pyrrolyl pyrazoles, bispyrazoles, and pyrazolyl isoxazoles—were prepared from 1‐aroyl‐2‐styrylsulfonylethenes, and the products were characterized by spectral parameters and elemental analyses.     

Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles

A new class of sulfonylmethane linked bisheterocycles were prepared and studied their antimicrobial activity.     

Synthesis of Amido‐linked Oxazolyl/Thiazolyl/Imidazolyl Pyrazoles and Isoxazoles

The amido‐linked oxazolyl/thiazolyl/imidazolyl pyrazoles and isoxazoles were prepared from the synthetic intermediates oxazolyl/thiazolyl/imidazolyl acrylamides adpoting1,3‐dipolar cycloaddition of nitrile imines and nitrile oxides.