Simultaneous Determination of Six Marker Compounds in Piper nigrum L. and Species Comparison Study Using High-Performance Thin-Layer Chromatography-Mass Spectrometry

JPC – Journal of Planar Chromatography – Modern TLC - The isolation and characterization of bioactive compounds from medicinal plants is usually a significant challenge in phytochemical...     

Design, Modeling, Fabrication, and Evaluation of the Air Amplifier for Improved Detection of Biomolecules by Electrospray Ionization Mass Spectrometry

Through a multi-disciplinary approach, the air amplifier is being evolved as a highly engineered device to improve detection limits of biomolecules when using electrospray ionization. Several key aspects have driven the modifications to the device through experimentation and simulations. We have developed a computer simulation that accurately portrays actual conditions and the results from these simulations are corroborated by the experimental data. These computer simulations can be used to predict outcomes from future designs resulting in a design process that is efficient in terms of financial cost and time. We have fabricated a new device with annular gap control over a range of 50 to 70 μm using piezoelectric actuators. This has enabled us to obtain better aerodynamic performance when compared to the previous design (2× more vacuum) and also more reproducible results. This is allowing us to study a broader experimental space than the previous design which is critical in guiding future directions. This work also presents and explains the principles behind a fractional factorial design of experiments methodology for testing a large number of experimental parameters in an orderly and efficient manner to understand and optimize the critical parameters that lead to obtain improved detection limits while minimizing the number of experiments performed. Preliminary results showed that several folds of improvements could be obtained for certain condition of operations (up to 34 folds).     

Nitromethane with IBX/TBAF as a nitrosating agent: synthesis of nitrosamines from secondary or tertiary amines under mild conditions

Aliphatic or aromatic N,N-disubstituted nitrosamine was generated in fair to excellent yield from the reaction of a secondary or tertiary amine with o-iodoxybenzoic acid (IBX) or o-iodosylbenzoic acid (IBA)/R(4)NX (X = halide) and nitromethane. The product yield was strongly influenced by both the halide of R(4)NX and iodanes. IBX gave a higher yield than IBA, while the halides follow F(-) > Cl(-) > Br(-) ～ I(-). Nitrous acid formed in situ from nitromethane and IBX (or IBA)/halides is likely responsible for the observed reaction.     

Development and Validation of a Planar Chromatographic Method with Reflectance Scanning Densitometry for Quantitative Analysis of Anastrozole in the Bulk Material and in Tablet Formulations

JPC – Journal of Planar Chromatography – Modern TLC - A new quantitative densitometric HPTLC method has been developed for analysis and determination of the stability of anastrozole,...     

ChemInform Abstract: On Compound Formation of M′O:M2O3. Part 11. Crystal Structure of BaIn2O4.

Single crystals of the title compound, obtained from a melt after reacting intimate mixtures of BaCO₃ and In₂O₃ at 840 °C (12 h), belong to the monoclinic space group P2₁/a with Z=16.     

ChemInform Abstract: Boron Occupied Condensed Clusters in Ta5Ge3By (y ≈ 0.7).

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.