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Sulphamethizole-Cyclodextrin-Hydroxy Propylmethyl Cellulose Multicomponent Complexes 总被引:4,自引:0,他引:4
Pose-Vilarnovo B. Rodríguez-Tenreiro Sánchez X Pérez-Marcos M. B. Torres-Labandeira J. J. 《Journal of Thermal Analysis and Calorimetry》2002,68(2):657-667
The effect of cyclodextrin complexation of sulphamethizole (SM) was studied. Two systems were prepared with two cyclodextrin
derivatives, β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HPBCD): binary complexes and multicomponent systems (cyclodextrins
and a hydroxylpropylmethyl cellulose K4M). Inclusion complexes were prepared by freeze-drying and characterized by thermal
analysis (DSC) and X-ray diffractometry. The presence of the polymer in the solution increases the effect of cyclodextrins
– specially BCD – on the solubility of SM. In solid state, binary inclusion complexes enhance the dissolution behaviour of
SM but, from the multi-component complexes, the polymer controls the release of the drug.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
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Pose-Vilarnovo B. Rodríguez-Tenreiro Sánchez C. Diéguez Moure N. Vila-Jato J. L. Torres-Labandeira J. J. 《Journal of Thermal Analysis and Calorimetry》2003,73(2):661-670
The effect of a hydrophilic polymer, hydroxypropylmethyl cellulose K4M, on the complexation of diclofenac sodium with b- and
hydroxypropyl-b-cyclodextrins has been studied. Multicomponent systems were prepared with the drug, both cyclodextrin and
the polymer. Phase solubility diagrams revealed the positive effect of the polymer on the complexation of the drug but this
effect was found after autoclaving the solutions. Solid inclusion complexes were prepared by freeze-drying and characterized
by thermal analysis (DSC) and X-ray diffractometry. In solid state, binary inclusion complexes enhance the dissolution behaviour
of diclofenac but, from the b-cyclodextrin multicomponent complex, the polymer controls the release of the drug. In the case
of hydroxy- propyl-b-cyclodextrin multicomponent system, the solubility of the drugs increases significantly compared with
the binary complex.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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