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Pandit S Kumar M Ponnusankar S Pal BC Mukherjee PK 《Biomedical chromatography : BMC》2011,25(9):959-962
Murraya koenigii leaves (Rutaceae) are widely used as food condiments in various food preparations in India. They possess a wide range of biological activities including antioxidant, antibacterial, anticancer, hypoglycemic and hypolipidemic activity. A rapid reverse‐phase high‐performance liquid chromatography (RP‐HPLC) method has been developed for quantitative estimation of mahanine and mahanimbine, two major bioactive alkaloids in this plant. The amounts of mahanine and mahanimbine were detected as 9.56 ± 1.04 and 4.32 ± 0.81% w/w in the extract, with the retention times of 6.26 ± 0.66 and 10.40 ± 0.95 minutes. The limits of detection and quantification were estimated to be 29.30 and 81.12 µg/mL and 1.67 and 6.31 µg/mL, respectively. This specific and precise validated method can be useful for the routine analysis and quantitative determination of mahanine and mahanimbine in this therapeutically potent medicinal plant. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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Nur Hanisah Mustafa Mahendran Sekar Shivkanya Fuloria M. Yasmin Begum Siew Hua Gan Nur Najihah Izzati Mat Rani Subban Ravi Kumarappan Chidambaram Vetriselvan Subramaniyan Kathiresan V. Sathasivam Srikanth Jeyabalan Subasini Uthirapathy Sivasankaran Ponnusankar Pei Teng Lum Vijay Bhalla Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(6)
Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemarrhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neuroprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development. 相似文献
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Pandit Subrata Mukherjee Pulok K. Gantait Arunava Ponnusankar Sivasankaran Bhadra Santanu 《平面色谱法杂志一现代薄层色谱法》2011,24(6):541-544
JPC – Journal of Planar Chromatography – Modern TLC - 相似文献
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