Green and one-pot synthesis of novel amidoalkyl naphthols using triethanolammonium acetate [(OHCH2CH2)3NH][OAc]) ionic liquid and their anti-H.pylori activity

Research on Chemical Intermediates - Nearly half of the world's population have been infected with Helicobacter pylori (H. pylori) which is known as the main cause of chronic gastritis,...     

Synthesis, antibacterial and antifungal activities of 3-aryl-5-(pyridin-3-yl)-4,5-dihydropyrazole-1-carbothioamide derivatives

A new series of 3-aryl-5-(pyridin-3-yl)-1-thiocarbamoyl-2-pyrazoline derivatives (4a-j) were prepared by the reaction of azachalcons 3a-j with thiosemicarbazide in ethanolic sodium hydroxide. The structure of synthesized compounds were confirmed by ¹H NMR and Mass spectral data. Their antibacterial activities against Escherichia coli (CTP 7624), Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12229), Pseudomonas aeruginosa (ATCC 9027), Bacillus subtilis (ATCC 1156) and Micrococcus luteus (ATCC 9341) were investigated. Antifungal activity of compounds against Candida albicans and Candida globrata were found to be inactive. Compounds 4a-j were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H ₃₇ Rv (ATCC 27294) in BACTEC 12B using a broth microdilution assay and Microplate Alamar Blue Assay (MABA). The preliminary results showed that compounds 4e, 4d and 4g had 87%, 93% and 92% inhibitory effect respectively.     

A new taxane diterpenoid from <Emphasis Type="Italic">Taxus baccata</Emphasis> growing in Iran

Chemical examination of the needles and young stems of the European yew Taxus baccata L. growing in Iran resulted in the isolation of one new taxane diterpenoid, 5α-cinnamoyloxy-2α,9α-dihydroxy-10β, 13α-diacetoxy-4(20),11-diene. The structure of this taxoid has been elucidated on the basis of spectroscopic studies.     

Taxezopidine G and 10-deacetyltaxezopidine G from Taxus baccata growing in Iran

A new taxoid, 10-deacetyltaxezopidine G, and a previously reported compound (Taxezopidine G) have been isolated from the needles and young stems of Taxus baccata L. growing in Iran, and the structures were determined on the basis of spectroscopic data. These two compounds were not previously encountered in Taxus baccata L. species. Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 321–322, July–August, 2006.