排序方式: 共有17条查询结果,搜索用时 31 毫秒
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Pessoa-Mahana H Núñez CU Araya-Maturana R Barría CS Zapata-Torres G Pessoa-Mahana CD Iturriaga-Vasquez P Mella-Raipán J Reyes-Parada M Celis-Barros C 《Chemical & pharmaceutical bulletin》2012,60(5):632-638
A series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine(1A) receptor (5-HT(1A)R) compounds (12b) and (12h) showed the highest 5-HT(1A) receptor affinity (IC(50)=15 nM). Molecular docking studies with all the compounds in a homology model of 5-HT(1A) showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate(3.32). 相似文献
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The Schmidt and Beckmann rearrangement of 3,4-dihydro-4,4-dimethyl-1(2H)-naphthalenones bearing oxygenated groups at the 5,8-positions, and some of their oximes are reported. Depending upon the structure of the substrates and the reaction conditions 4,5-dihydro-3H-naphth[1,8-cd]isoxazol, benzazepin-2-one and 5,6-dihydro-7H-tetrazolo[1,5-a][2]benzazepine derivatives were generated. 相似文献
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A. Álvarez-Lueje C. Zapata-Urzúa S. Brain-Isasi M. Pérez-Ortiz L. Barros H. Pessoa-Mahana M.J. Kogan 《Talanta》2009,79(3):687-258
The present study addresses the electrochemical behavior and the analytical applications of six 2-nitrophenylbenzimidazole derivatives with activity against Trypanosoma cruzi. When studied in a wide range of pH, by differential pulse polarography, tast polarography and cyclic voltammetry, these compounds exhibited two irreversible cathodic responses. With analytical purposes, the differential pulse polarography mode was selected, which exhibited adequate analytical parameters of repeatability, reproducibility and selectivity. The percentage of recovery was in all cases over 99%, and the detection and quantitation limits were at the level of 1 × 10−7 mol L−1 and 1 × 10−6 mol L−1, respectively. In addition, the differential pulse polarography method was successfully applied to study the hydrolytic degradation kinetic of one of the tested compounds. Activation energy, kinetic rate constants at different temperatures and half-life values of such application are reported. 相似文献
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Ramiro Araya-Maturana Jorge Heredia-Moya Hernán Pessoa-Mahana Boris Weiss-López Juan Carlos Muñoz 《Acta Crystallographica. Section C, Structural Chemistry》2005,61(4):o237-o239
The title compound, C12H7NO3, consists of a chromone moiety substituted in position 3 with an acrylonitrile group in a Z configuration. The two planar groups are twisted with respect to one another. The only significant hydrogen bond in the structure is an intramolecular O—H·O bond. π–π contacts connecting aromatic groups and C—H·O intermolecular weak interactions lead to a supramolecular layer arrangement. 相似文献
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Dobado JA Gómez-Tamayo JC Calvo-Flores FG Martínez-García H Cardona W Weiss-López B Ramírez-Rodríguez O Pessoa-Mahana H Araya-Maturana R 《Magnetic resonance in chemistry : MRC》2011,49(6):358-365
A set of regioisomeric pairs of tricyclic hydroquinones, analogues of antitumor 9,10-dihydroxy-4,4-dimethyl-5,8-dihydroanthracen-1(4H)-one (1) and other derivatives, were synthesized and their regiochemistry and NMR spectra assigned by using (1)H-detected one-bond (C-H) HMQC and long-range C-H HMBC, in good agreement with theoretical O3LYP/Alhrichs-pVTZ calculations. The 5-hydroxymethyl derivatives (11, 15, 19) showed a (3)J(H, H) coupling constant of methylene protons evidencing the presence of a seven-membered intramolecular hydrogen bonded ring, not observed for the 8-hydroxymethyl isomers. 相似文献
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A structural failure problem was solved using an integrated and iterative program of testing and analysis. The steps taken in solving the problem were: analytical calculations; operational testing; qualifications of analytical results; problem identification; design of corrective action; and confirmatory testing. 相似文献
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Cinthia Quiroga-Campano Horacio Gómez-Machuca Carolina Jullian Julio De la Fuente Hernán Pessoa-Mahana Claudio Saitz 《Journal of inclusion phenomena and macrocyclic chemistry》2014,79(1-2):161-169
The present work describes a study of complexation efficiency and selectivity of calix[4]arenes bearing benzoimidazolyl, benzothiazolyl, and benzoxazolyl heterocycles (5–7) towards several selected metal ions using fluorescence and UV–Vis spectroscopy. The binding ability of calixarene derivatives 5–7 toward selected divalent metal ions such as Ca, Cd, Pb, Ni, Mg, Mn, Co, Fe and Zn has been investigated by fluorescence spectroscopic techniques. Fluorescent chemosensor ability of three calixarene derivatives was highly selective for Pb (II) in contrast with other divalent metal studied. The highest association constant corresponds to benzoxazolyl calixarene derivative 7, with a Ka of (1.37 ± 0.06) × 104 mol?1 L and detection limit for lead of 1.14 ± 0.05 mg L?1 in methanol being acceptable for the recognition of this metal at micromolar concentrations. 相似文献
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We have performed extensive small-angle neutron scattering (SANS) diffraction studies of the vortex lattice in single crystal
YNi2B2C for B‖c. High-resolution SANS, combined with a field-oscillation vortex lattice preparation technique, allows us to separate Bragg
scattered intensities from two orthogonal domains and accurately determine the unit cell angle, β. The data suggest that upon increasing field there is a finite transition width where both low- and high-field distorted
hexagonal vortex lattice phases, mutually rotated by 45°, coexist. The smooth variation of diffracted intensity from each
phase through the transition corresponds to a redistribution of populations between the two types of domains. 相似文献
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