Synthesis of Pyrimido[6,1-a]isoquinolines by the Reaction of Thriethyl Orthoformate with Enamines of 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series

Russian Journal of Organic Chemistry - Boiling (Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides in AcOEt/Ac2O leads involves annelation of the pyrimidine ring to form...     

Synthesis and Acylation for Enaminoketohydrazides Derived from 2,2-Dialkyl-2,3-dihydrobenzo[f]isoquinolines

Russian Journal of Organic Chemistry - The reaction of 6,6-dialkyl-5,6-dihydrobenzo[f]pyrrolo[2,1-a]isoquinoline-8,9-diones with hydrazine is used to prepare enaminoketohydrazides of the...     

Synthesis of 4-[(3,3-Dimethyl-3,4-dihydroisoquinolin-1-yl)sulfanyl]anilines by the Ritter Reaction

Russian Journal of Organic Chemistry - The Ritter cyclocondensation of 2-methyl-3-phenylpropan-2-ol with 4-isocyanatoaniline, 2-methyl-4-thiocyanatoaniline, and ethyl 4-amino-3-thiocyanatobenzoate...     

Threshold intensity and coefficient of raman scattering amplification in a high-<Emphasis Type="Italic">Q</Emphasis> bilayer microresonator during the formation of internal and external submicron photonic jets: A photonic nanojet in the near field

Using quantum and semiclassical approaches, the energy excitation threshold for induced Raman scattering is estimated and a relationship between the excitation threshold and the concentration of optically active molecules in a bilayer microresonator is established. Estimates are made during the formation of specially configured optical fields: internal and external photonic nanojets. Based on the amount of stored energy per mode and the value of the threshold intensity, an additional generalized selection rule for whispering gallery modes is suggested. It is shown that the bilayer microresonator can focus incident radiation (laser pumping) into a submicron focal volume at a low threshold intensity.     

The Effect of Betulin Diphosphate in Wound Dressings of Bacterial Cellulose-ZnO NPs on Platelet Aggregation and the Activity of Oxidoreductases Regulated by NAD(P)+/NAD(P)H-Balance in Burns on Rats

The inhibition of platelet aggregation, and the activity of oxidoreductases and microhemocirculation in a burn wound on the treatment of burns with wound dressings based on bacterial nanocellulose (BC)-zinc oxide nanoparticles (ZnO NPs)-betulin diphosphate (BDP) were studied. The control of the treatment by BC-ZnO NPs-BDP on burned rats by the noninvasive DLF method showed an increase in perfusion and the respiratory component in wavelet spectra, characterizing an improvement in oxygen saturation in the wound. The study on the volunteers’ blood found the inhibition of ADP-induced platelet aggregation by 30–90%. Disaggregation depends on the dose under the action of the ionized form of BDP and ZnO NPs-BDP in a phosphate buffer; it was reversible and had two waves. It was shown on rats that the specific activity of LDH_reverse and LDH_direct (control-intact animals) on day 21 of treatment increased by 11–38% and 23%, respectively. The LDH_reverse/LDH_direct ratio increased at BC-ZnO NPs-BDP treatment, which characterizes efficient NAD+ regeneration. AlDH activity increased significantly in the first 10 days by 70–170%, reflecting the effectiveness of the enzyme and NAD+ in utilizing toxic aldehydes at this stage of burn disease. The activities of GR and G6PDH using NADP(H) were increased with BC-ZnO NPs-BDP treatment.