Synthesis,Physicochemical and Pharmacological Properties of N,N',N', N''-Substituted Amides of 1,1,3,3-Propanetetracarboxylic Acid

By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N',N'-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.     

Michael Addition of N,N'-Dibenzylmalonamide to N-Aryl(alkyl)crotonamides

Russian Journal of Organic Chemistry -