Nonvanishing cohomology and classes of Gorenstein rings

We give counterexamples to the following conjecture of Auslander: given a finitely generated module M over an Artin algebra Λ, there exists a positive integer n_M such that for all finitely generated Λ-modules N, if Ext_Λⁱ(M,N)=0 for all i?0, then Ext_Λⁱ(M,N)=0 for all i?n_M. Some of our examples moreover yield homologically defined classes of commutative local rings strictly between the class of local complete intersections and the class of local Gorenstein rings.     

v-Triazolines. XXXIX . 1,2,4-Triaryl-3-aminopyrroles. Unusual Reaction Products in the Pyrolysis of 5-Amino-v-triazolines and the Crystal Structure of 2-(3-Morpholin-4-yl-2,4-pyrrol-1-yl)benzonitrile

Pyrolysis of 4-aryl-5-amino-v-triazolines affords, generally, amidines and/or benzanilides. Pyrolysis of 4-aryl-5-morpholino-v-triazolines 6 , together with the expected amidines 7 and/or aryanilides 8 , produced the morpholinopyrroles 9 . The reaction mechanism of this unusual transformation is discussed. Influence of solvent dipole moment in pyrrole formation is suggested. Pyrrole 9a [i.e. 2-(3-morpholin-4-yl-2,4-pyrrol-1-yl)-benzonitrile] has been fully characterized and its molecular structure has been determined by X-ray diffraction analysis.     

FT IR ATR Study of Molecular Interactions in the Urea/Dimethyl Sulfoxide and Urea/Diethyl Sulfoxide Binary Systems

FT IR ATR spectra of urea/dimethyl sulfoxide and urea/diethyl sulfoxide mixtures in the S=O and N—H stretching vibration regions at different molar ratios have been measured. On the basis of the band deconvolution data, various types of intermolecular associated forms, including dimers and hydrogen-bonded urea–sulfoxide complexes, have been revealed. The latter has been confirmed also by ab initio calculations.     

Solution conformation of a nitrobenzoxadiazole derivative of the polyene antibiotic nystatin: a FRET study

Nystatin is a polyene antibiotic frequently applied in the treatment of topical fungal infections. In this work, a 7-nitrobenz-2-oxa-1,3-diazole (NBD) hexanoyl amide derivative of nystatin was synthesized and its detailed photophysical characterization is presented. The average conformation of the labelled antibiotic in tetrahydrofuran, ethanol and methanol was determined by intramolecular (tetraene to NBD) fluorescence resonance energy transfer measurements. At variance with the literature [Can. J. Chem. 63 (1985) 77-85], it was concluded that there is no need to invoke a solvent-dependent conformational equilibrium between extended and closed conformers of the antibiotic, because the mean tetraene-to-NBD separating distance was found to remain constant (approximately 18 A) in all the solvents studied. In addition, the large solvent dependence of the fluorescence anisotropy observed for the non-derivatized nystatin, was rationalized on the basis of the prolate ellipsoidal geometry of the molecule. It was concluded that the rod shaped and amphipathic antibiotic remains monomeric in different solvents within the concentration range studied (2-20 microM).     

Metallo-Drugs in Cancer Therapy: Past,Present and Future

Cancer treatments which include conventional chemotherapy have not proven very successful in curing human malignancies. The failures of these treatment modalities include inherent resistance, systemic toxicity and severe side effects. Out of 50% patients administrated to chemotherapy, only 5% survive. For these reasons, the identification of new drug designs and therapeutic strategies that could target cancer cells while leaving normal cells unaffected still continues to be a challenge. Despite advances that have led to the development of new therapies, treatment options are still limited for many types of cancers. This review provides an overview of platinum, copper and ruthenium metal based anticancer drugs in clinical trials and in vitro/in vivo studies. Presumably, copper and ruthenium complexes have greater potential than Pt(II) complexes, showing reduced toxicity, a new mechanism of action, a different spectrum of activity and the possibility of non-cross-resistance. We focus the discussion towards past, present and future aspects.     

Two-stage latexes of polystyrene acrylates

ABSTRACT

The modification of decomposition rate of the potassium persulfate initiator during the synthesis of “two-stage latexes” polystyrene-ethyl acrylate (EtA) of butyl acrylale (BuA) and of 2-ethylhexyl acrylate (EHA) is studied. This rate is minimum for BuA and maximum for EHA, in good agreement with the value of solubility parameters. The appearance of poryacrvlaf.es determines the existence of water bonded to the polar polymer. The amount of water bonded increases in the sequence PEtA?PBuA?PEHA, function of the modification of the diameters of the particles resulted from the latexes obtained.     

Synthesis of (1′S*,2R*,3R*)- and (1′S*,2R*,3S*)-N-arylsulfonyl-2-(1′-halogenethyl)-3-methylindolines and their selective toxicity against SH-SY5Y cell line

N-tosyl-2- and N-tosyl-4-halogen-substituted derivatives of 2-(1-methylbut-2-en-1-yl)aniline were synthesized and their molecular iodine-mediated cyclization was investigated. The cyclization upon interaction of N-tosyl-6-methyl-2-(1-methylbut-2-en-1-yl)aniline with molecular iodine in methyl tert-butyl ether or acetonitrile was studied, as well as the interaction of this sulfonamide with N-bromosucinimide in dichloromethane. Synthesized (2R*,3R*)- and (2R*,3S*)-N-arylsulfonyl-2-(1-halogenoethyl)-3-methylindoline derivatives showed cytotoxic activity against HEK293 cells, SH-SY5Y, Jurkat, and HepG2 cell lines. The compounds (2R*,3S*)-N-arylsulfonyl-7-bromo-2-(1-halogenoethyl)-3-methylindoline cis- 4a , stereoisomeric (2R*,3R*)-trans- 4h and (2R*,3S*)-N-tosyl-7-chloro-2-(1-halogenoethyl)-3-methylindoline cis- 4h demonstrated selective toxicity against SH-SY5Y cell line (IC₅₀ ≈ 3 ÷ 5 μM), and did not affect HEK293, Jurkat, and HepG2 cells.     

Cholest-4,14-dien-15,20ε-diol-3,16-dione,a novel polyoxygenated marine steroid which easily loses the side chain

The title compound has been isolated from the Mediterranean gorgonian $\text{Leptogorgia sarmentosa}$; upon acetylation it affords a dehydration product and an androstane derivative.     

Microfluidic sensor based on integrated optical hollow waveguides

A simple integrated optical refractometric sensor based on hollow-core antiresonant reflecting optical waveguides is proposed. The sensor uses the antiresonant reflecting guidance mechanism and permits one to measure the refractive index of a liquid filling the core by simply monitoring the transmitted spectrum. The device has been made with standard silicon technology, and the experimental results confirm numerical simulations performed in one- and two-dimensional geometry. The sensor exhibits a linear response over a wide measurement range (1.3330-1.4450) and a resolution of 9 x 10(-4) and requires a small analyte volume.     

Chlamydomonas reinhardtii genetic variants as probes for fluorescence sensing system in detection of pollutants

The unicellular green alga Chlamydomonas reinhardtii is employed here for the setup of a biosensor demonstrator based on multibiomediators for the detection of herbicides. The detection is based on the activity of photosystem II, the multienzymatic chlorophyll–protein complex located in the thylakoid membrane that catalyzes the light-dependent photosynthetic primary charge separation and the electron transfer chain in cyanobacteria, algae, and higher plants. Several C. reinhardtii mutants modified on the D1 photosystem II protein are generated by site-directed mutagenesis and experimentally tested for the development of a biosensor revealing the modification of the fluorescence parameter (1 − V _J) in the presence of herbicides. The A250R, A250L, A251C, and I163N mutants are highly sensitive to the urea and triazine herbicide classes; the newly generated F255N mutant is shown to be especially resistant to the class of urea. It follows that the response of the multibiomediators is associated to a particular herbicide subclass and can be useful to monitor several species of pollutants.