Urea Salts with 1-Hydroxyethylidene Diphosphonic Acid

Russian Journal of General Chemistry - The reaction of urea with 1-hydroxyethylidene diphosphonic acid in the ratios of 1 : 1, 1 : 2, 1 : 3 was first studied. As a result of the reactions, the...     

New Synthesis of 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione Using Etidronic Acid as a “Green” Catalyst

Russian Journal of Organic Chemistry - A new method has been developed for the synthesis of 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione in 62% yield using etidronic acid...     

Synthesis in the phenothiazine series

A method was developed for the preparation of 3,7-diamino-10-acetylphenothiazine 5-oxide by the reduction of 3,7-dinitro-10-acetylphenothiazine 5-oxide with hydrazine hydrate in the presence of a nickel catalyst.See [1] for communication XXXIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 325–327, March, 1972.     

Synthesis of glycolurils and hydantoins by reaction of urea and 1, 2-dicarbonyl compounds using etidronic acid as a “green catalyst”

Most of the known methods for the synthesis of heterocyclic compounds have disadvantages, such as a long reaction time and aggressive conditions. We have developed a new, rather simple and efficient method for the synthesis of a number of glycoluryls and hydantoins in water using a etidronic acid (HEDP) as “Green catalyst.” So, for the first time, the condensation reaction of ureas with 1, 2-dicarbonyl compounds was carried out in the presence of HEDP. Also based on NMR studies, a chemism of these reactions, which is stepwise, is proposed. It has been established that the optimal conditions for the synthesis of glycoluryls and hydantoins using HEDP are: temperature 80°C-90°C, 40-20 minutes, and the ratio of urea and HEDP is 1:1. In all cases, the remaining aqueous filtrate containing HEDP after the reaction can be reused for other cycles synthesis of glycoluril and other compounds, because HEDP is not converted during the reaction.