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Pathak TP  Osiak JG  Vaden RM  Welm BE  Sigman MS 《Tetrahedron》2012,68(26):5203-5208
An acid-catalyzed hydroarylation reaction of vinyl indoles is reported, which tolerates a wide range of heterocycles as the exogenous nucleophile such as indoles, pyrroles, and indolizines. The method rapidly accesses the biologically relevant bisindolylmethane scaffold in good to excellent yields. Evaluation of the biological activity of several synthesized analogues reveals cytotoxic activity against and selectivity for the MCF-7 breast cancer cell line.  相似文献   
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In this article we discuss the following question “When do different orderings of the rational function field R(X) (where R is a real closed field) induce the same ?-place?” We use this to show that if R contains a dense real closed subfield R′, then the spaces of ?-places of R(X) and R′(X) are homeomorphic. For the function field K = R(X), we prove that its space M(K) of ?-places is metrizible if and only if R contains a countable dense subfield. Moreover, we show that this condition is neccessary for the metrizability of M(F) for any function field F of transcendence degree 1 over R.  相似文献   
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In this paper we introduce a two-sided Arnoldi method for the reduction of high order linear systems and we propose useful extensions, first of all a stopping criterion to find a suitable order for the reduced model and secondly, a selection procedure to significantly improve the performance in the multi-input multi-output (MIMO) case. One application is in micro-electro-mechanical systems (MEMS). We consider a thermo-electric micro thruster model, and a comparison between the commonly used Arnoldi algorithm and the two-sided Arnoldi is performed.  相似文献   
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This is the report of Heavy Ion Physics and Quark-Gluon Plasma at WHEPP-09 which was part of Working Group-4. Discussion and work on some aspects of quark-gluon plasma believed to have created in heavy-ion collisions and in early Universe are reported.  相似文献   
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The main aim of the paper is to find an explicit formula for the number of orderings of higher level. Among others, we discuss the relationship between the number of orderings of higher level and the number of orderings of level 1. We also construct a field with a given possible number of orderings of higher level. Received: 10 December 2004  相似文献   
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Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons.  相似文献   
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