Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles

An acid-catalyzed hydroarylation reaction of vinyl indoles is reported, which tolerates a wide range of heterocycles as the exogenous nucleophile such as indoles, pyrroles, and indolizines. The method rapidly accesses the biologically relevant bisindolylmethane scaffold in good to excellent yields. Evaluation of the biological activity of several synthesized analogues reveals cytotoxic activity against and selectivity for the MCF-7 breast cancer cell line.     

Metrizability of Spaces of ℝ-places of Function Fields of Transcendence Degree 1 Over Real Closed Fields

In this article we discuss the following question “When do different orderings of the rational function field R(X) (where R is a real closed field) induce the same ?-place?” We use this to show that if R contains a dense real closed subfield R′, then the spaces of ?-places of R(X) and R′(X) are homeomorphic. For the function field K = R(X), we prove that its space M(K) of ?-places is metrizible if and only if R contains a countable dense subfield. Moreover, we show that this condition is neccessary for the metrizability of M(F) for any function field F of transcendence degree 1 over R.     

A two-sided Arnoldi algorithm with stopping criterion and MIMO selection procedure

In this paper we introduce a two-sided Arnoldi method for the reduction of high order linear systems and we propose useful extensions, first of all a stopping criterion to find a suitable order for the reduced model and secondly, a selection procedure to significantly improve the performance in the multi-input multi-output (MIMO) case. One application is in micro-electro-mechanical systems (MEMS). We consider a thermo-electric micro thruster model, and a comparison between the commonly used Arnoldi algorithm and the two-sided Arnoldi is performed.     

Working group report: Heavy-ion physics and quark-gluon plasma

This is the report of Heavy Ion Physics and Quark-Gluon Plasma at WHEPP-09 which was part of Working Group-4. Discussion and work on some aspects of quark-gluon plasma believed to have created in heavy-ion collisions and in early Universe are reported.     

A note on number of orderings of higher level

The main aim of the paper is to find an explicit formula for the number of orderings of higher level. Among others, we discuss the relationship between the number of orderings of higher level and the number of orderings of level 1. We also construct a field with a given possible number of orderings of higher level. Received: 10 December 2004     

结构非线性分析中求解预定荷载水平的改进弧长法

本文对目前广泛应用于结构非线性分析之中的弧长法进行改进。改进后的弧长法除保持原有优点外，能够在自动跟踪结构非线性平衡路径的同时，进一步求得位于结构平衡睡径任一区段的任意预先指定的荷载水平及相应的变形。本文的方法可以推广应用于求解预先指定的应力或位移。数值算例表明了本文方法的计算精度、效率及可靠性。