Inclusion complexing by water-soluble β-cyclodextrin polymers

Cross-linked -cyclodextrin with a molecular weight of less than 10000 has good solubility in water, and it is a better inclusion complexing agent than the parent -cyclodextrin. By including lipophilic guest molecules into the apolar cyclodextrin cavity, their apparent lipophilicity is reduced because the outer surface of the molecular wrapping (the crosslinked -CD) is highly hydrophilic. The relative stability of the inclusion complexes can be rapidly determined by reversed-phase thin-layer chromatography. The reversed-phase TLC behaviour of 25 triphenylmethane derivatives and analogues were studied in the presence of -cyclodextrin polymers containing neutral and carboxyl groups. Increasing the molecular weight results in an increased complex-forming capacity. The carboxyl group modifies the accessibility of the CD cavity which in turn results in increased or decreased complex stability, depending on the guest molecule. The presence of organic solvents diminishes the stability of the CD complexes.     

Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens

Background  

In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal influence of estrogen). This study examined the influence of phytoestrogens (estrogen-like plant compounds) on VSM, utilizing radial arm-maze methods to examine varying aspects of memory. Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined.     

Investigations involving shock waves generation and shock pressure measurement in direct ablation regime and confined ablation regime

Recent investigations involving shock waves generation and shock pressure measurement in direct ablation regime and confined ablation regime for aluminium, copper, titanium and steel (40C130) materials are reported. Experimental measurements demonstrated that in direct ablation regime the peak pressures typically are less than 10 Pa when the incident laser intensity is about 10 W/cm and the time duration of the applied pressure is roughly equal to the laser pulse duration. It is shown that confinement of the surface with a transparent overlayer provided an effective method of enhancing laser-induced shock waves pressure in the target material with an order of magnitude for same laser intensity. Also, in this second regime, the pressure is applied over a period much longer than the laser-pulse duration. As an application measurements of the hardness of target surface before and after laser irradiation in direct ablation regime and confined ablation regime are given, and it is shown that the maximum value of surface hardness is obtained in confined ablation regime. Received 10 March 2001 / Accepted 13 April 2001     

Magnetic dipole moments near Sn: Measurement on isomeric 11/2 states in odd-A Te and Te by NMR/ON

On-line low temperature nuclear orientation (OLNO) experiments have been performed on the odd-A Te isotopes ¹³¹Te and ¹³³Te using the technique of nuclear magnetic resonance on oriented nuclei (NMR/ON). The magnetic moments of the isomeric 11/2⁻ states have been measured extending the known data on these states in the Te isotopes up to the neutron shell closure at N = 82. The contribution to the 11/2⁻ magnetic moment in ¹³³Te due to core polarisation is calculated using an RPA shell model as well as corrections to the magnetic dipole operator caused by mesonic exchange currents. The neutron number dependence of the magnetic moments of the 11/2⁻ isomers in heavy Te isotopes is discussed in terms of particle-core coupling model (PCM) calculations.     

Representations of finite p-groups over the ring of formal power series with integral p-adic coefficients

A classification is given of the representations of the cyclic group of order p over the ring _p [[x]] of formal power series with integral p-adic coefficients and it is proved that in the other cases the problem of representations of a finite, p-group over _P [[x₁,...x_n]] is wild.Translated from Ukrainskii Matematicheskii Zhurnal, Vol. 44, No. 6, pp. 753–765, June, 1992.     

Ion exhange and molecular sorption of oxalic acid with a highly basic anion exchanger

Ab initio modeling of a matrix fragment of resin and geometry optimization of the molecular structure of oxalic acid were performed. The isotherm of oxalic acid sorption with AV-17-8 anion exchange resin was obtained by the variable concentrations technique. The ion-exchange and molecular components of sorbate fixation with the ion exchanger were determined. The hydration of the highly basic anion exchanger that absorbed different quantities of dicarboxylic acid was evaluated by the centrifuging method. The dependence of the amount of water and sorbate concentration in the resin was linear antibatic.     

New approach for the clinical monitoring of 25‐hydroxyvitamin D3 and 25‐hydroxyvitamin D2 by ultra high performance liquid chromatography with MS/MS based on the standard reference material 972

Biomarkers, 25‐hydroxyvitamin D₃ and 25‐hydroxyvitamin D₂, are important indicators of the vitamin D general status and are monitored in several pathophysiological disorders, such as osteoporosis, diabetes, heart disease, etc. A novel ultra‐HPLC with MS/MS methodology for the analysis of 25‐hydroxyvitamin D derivatives coupled with a very simple and highly rapid sample preparation step was developed. Analytical parameters obtained showed linearity (R²) above 0.999 for both vitamins with accuracies between 95.8 and 102%. The LODs were as low as 0.22 and 0.67 nmol/L for 25‐hydroxyvitamin D₃ and 25‐hydroxyvitamin D₂, respectively. Intra‐assay precision (%RSD) was lower than 4.5%, and inter‐assay precision (%RSD) was lower than 6.5%. The feasibility of the developed methodology to be applied in clinical routine analysis has been proved by its application in blood samples from non‐agenarian patients, patients with familial hypercholesterolemia and patients suffering from age‐related macular degeneration.     

The application of homotopy analysis method to solve nonlinear differential equation governing Jeffery–Hamel flow

In this paper Jeffery–Hamel flow has been studied and its nonlinear ordinary differential equation has been solved through homotopy analysis method (HAM). The obtained solution in comparison with the numerical ones represents a remarkable accuracy. The results also indicate that HAM can provide us with a convenient way to control and adjust the convergence region.