Reconstruction of physics objects at the Circular Electron Positron Collider with Arbor

After the Higgs discovery, precise measurements of the Higgs properties and the electroweak observables become vital for the experimental particle physics. A powerful Higgs/Z factory, the Circular Electron Positron Collider (CEPC) is proposed. The Particle Flow oriented detector design is proposed to the CEPC and a Particle Flow algorithm, Arbor is optimized accordingly. We summarize the physics object reconstruction performance of the Particle Flow oriented detector design with Arbor algorithm and conclude that this combination fulfills the physics requirement of CEPC.     

Principal component analysis of the 13C NMR spectra of enamino ketones

The ¹³C NMR spectra of eleven 3-N,N-dialkylamino-5,5-dimethylcyclohex-2-en-1-ones have been determined. The chemical shifts of the three sp² carbons and of the two methylene carbons on the cyclohexenone moiety have been subjected to factor analysis. Two factors are necessary and sufficient to account for more than 93% of the total variance. The more important axis (79%) corresponds to a factor closely related to the inductive and steric effects of the alkyl nitrogen substituents. The second parameter is more difficult to interpret and could correspond to the ‘ipso effects’ of amino groups.     

Sodium-iron fluorophosphate glasses: Part 2: EPR and mössbauer resonance study

EPR and Mössbauer measurements have been performed on sodium-iron fluorophosphate glasses. Mössbauer spectra show the presence of Fe³⁺ and Fe²⁺ both in octahedral coordination sites. However, for low iron concentration, EPR suggests a small number of Fe³⁺ tetrahedra coexisting with Fe³⁺ octahedra. On the basis of these results, Fe³⁺ tetrahedrally and/or octahedrally coordinated, connected with P(O, F)₄ tetrahedra would behave as a network-former cation, whereas Fe²⁺ would substitute for Na⁺ as a netweork-modifier. Long range magnetic order previously observed by magnetic measurements has been confirmed for iron-rich compositions.     

New silver tellurite glasses

The glass forming ranges in the TeO₂-AgO_0.5 and TeO₂-AgO_0.5-AgI systems have been assessed for two cooling rates; results based on heat capacity and electrical conductivity measurements as well as derived from infrared spectroscopy are presented. The ternary glasses are excellent conductors due to the presence of Ag⁺ ions mainly supplied by AgI. The decrease in C _P with increasing AgI-content suggests the presence of AgI microdomains which are finely distributed and do not contribute to the configurational heat capacity change. Fast motion of Ag⁺ ions (low activation energy) occurs in the glassy matrix which shows slow structural relaxation (high activation barrier).This research is performed within the frame of a P.I.R.M.A.T. action of the CNRS.     

A partial wave analysis of the Q enhancement in the reaction K−p→K−π−π+p at 3.95 GeV/c

We present results on the partial wave analysis of the Kππ system in the mass interval 1.1 to 1.6 GeV/c², in the reaction K^?p→K^?π^?π⁺p at 3.95 GeV/c. Our results are compared to those at higher energies, and we note certain differences. In particular, we find very much less of the ?K decay mode of the 1⁺S 0⁺ wave. In addition, the relative phase between the 1⁺S 0⁺ (K¹π) and the 2⁺D 1⁺ (K¹π) wave has been measured.     

Daubechies wavelets for high performance electronic structure calculations: The BigDFT project

In this contribution we will describe in detail a Density Functional Theory method based on a Daubechies wavelets basis set, named BigDFT. We will see that, thanks to wavelet properties, this code shows high systematic convergence properties, very good performances and an excellent efficiency for parallel calculations. BigDFT code operation are also well-suited for GPU acceleration. We will discuss how the problematic of fruitfully benefit of this new technology can be match with the needs of robustness and flexibility of a complex code like BigDFT. This work may be of interest not only for expert in electronic structure calculations, but may also provide feedback to the wider community of high performance scientific computing.     

Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans

Phenotyping based on drug metabolism activity appears to be informative regarding mechanism‐based interactions during drug development. We report here the first steps of the development of the innovative CIME cocktail. This cocktail is designed not only for the major cytochrome P450, with caffeine, amodiaquine, tolbutamide, omeprazole, dextromethorphan and midazolam as substrates of CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A, respectively, but also phase II enzymes UGT 1A1/6/9 with acetaminophen, P‐gp and OATP1B1 with digoxin and rosuvastatin, and renal function with memantine. An assay combining ultra‐performance liquid chromatography using a 1.7 µm particle size column with tandem mass spectrometry (UPLC/MS/MS) was set up for the simultaneous quantification of the 20 substrates and metabolites after extraction from human plasma using solid‐phase extraction. The method was validated in the spirit of the FDA guidelines. Mean accuracy ranged from 87.7 to 115%, the coefficient of variance (CV%) of intra‐ and inter‐run from 1.7 to 16.4% and from 1.6 to 14.9%, respectively, and for the limit of quantification (LOQ) with ten lots of plasma, accuracy ranged from 84 to 115% and CV% precision was <16%. Short‐term stability was evaluated in eluate (4 h, room temperature), plasma (24 h, room temperature), the autosampler (24 h, 4°C) and in three freeze/thaw cycles in plasma. All except three analytes were stable under these conditions. For the three others a specific process can be followed. This robust, fast and sensitive assay in human plasma provides an analytical tool for ten‐probe drugs of the CIME cocktail. Clinical samples will be assayed in the near future using this new assay method. Copyright © 2010 John Wiley & Sons, Ltd.     

Kerr-like nonlinearity induced via terahertz generation and the electro-optical effect in zinc blende crystals

A model is proposed to account for Kerr-like nonlinearity induced by femtosecond pulses via terahertz generation and electro-optical effect. This phenomenon, so far overlooked, is evidenced in a zinc blende single crystal with a heterodyne optical Kerr effect setup. The spectral evolution of this phenomenon as well as its noninstantaneous response character are reported. Its competition with a third-order optical Kerr effect is demonstrated.     

Diode-pumped regenerative amplifier delivering 100-mJ single-mode laser pulses

We report on a side-pumped Nd:phosphate laser regenerative amplifier that delivers laser pulses of as much as 100 mJ in a single TEM mode. The laser beam is mode matched to the amplification medium by an intracavity fused-silica phase plate for mode shaping and a telescope for adjustment of the beam mode to the amplification rod section such that most of the energy stored in the rod is transferred to the laser pulses. As a result of the good overlap and the low loss, an optical-to-optical conversion efficiency of as much as 10% was measured for a pumping current of 80 A and greater than 100-mJ output pulses.