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1.
We present an iterative algorithm (BIN) for scaling all the rows and columns of a real symmetric matrix to unit 2-norm. We study the theoretical convergence properties and its relation to optimal conditioning. Numerical experiments show that BIN requires 2–4 matrix–vector multiplications to obtain an adequate scaling, and in many cases significantly reduces the condition number, more than other scaling algorithms. We present generalizations to complex, nonsymmetric and rectangular matrices. 相似文献
2.
Oren?Regev Jean-Fran?ois?Gohy Bas?G.?G.?Lohmeijer Sunil?K.?Varshney Dominique?H.?W.?Hubert Peter?M.?Frederik Ulrich?S.?SchubertEmail author 《Colloid and polymer science》2004,282(4):407-411
Metallo-supramolecular diblock copolymers consisting of a polystyrene (PS) block connected to a poly(ethylene oxide) (PEO) block by a bis(terpyridine)ruthenium complex (PS20-[Ru]-PEO
y
) were used to prepare aqueous micelles. The length of the PS block was kept constant, while two PEOs of different molecular weight were used. The resulting hydrated micelles and aggregates were characterized by a combination of cryogenic transmission electron microscopy (cryo-TEM) and dynamic light scattering measurements. The results were compared to those obtained for a covalent counterpart (PS22-b-PEO70). Cryogenic transmission electron microscopy allowed visualization of the PS core of the micelles. Moreover, the aggregates result from clustering of individual micelles. 相似文献
3.
Stefan Mommer Kamil Sokoowski Magdalena Olesiska Zehuan Huang Oren A. Scherman 《Chemical science》2022,13(30):8791
Extended polymeric structures based on redox-active species are of great interest in emerging technologies related to energy conversion and storage. However, redox-active monomers tend to inhibit radical polymerisation processes and hence, increase polydispersity and reduce the average molecular weight of the resultant polymers. Here, we demonstrate that styrenic viologens, which do not undergo radical polymerisation effectively on their own, can be readily copolymerised in the presence of cucurbit[n]uril (CB[n]) macrocycles. The presented strategy relies on pre-encapsulation of the viologen monomers within the molecular cavities of the CB[n] macrocycle. Upon polymerisation, the molecular weight of the resultant polymer was found to be an order of magnitude higher and the polydispersity reduced 5-fold. The mechanism responsible for this enhancement was unveiled through comprehensive spectroscopic and electrochemical studies. A combination of solubilisation/stabilisation of reduced viologen species as well as protection of the parent viologens against reduction gives rise to the higher molar masses and reduced polydispersities. The presented study highlights the potential of CB[n]-based host–guest chemistry to control both the redox behavior of monomers as well as the kinetics of their radical polymerisation, which will open up new opportunities across myriad fields.Extended polymeric structures based on redox-active species are of great interest in emerging technologies related to energy conversion and storage.Polyviologens are redox-active polymers based on N-substituted bipyridinium derivatives which have emerged as promising materials for energy conversion and storage.1–5 Their physicochemical properties can be adjusted through copolymerisation of the redox-active viologen monomers.6–8 The resultant materials are stable, water soluble and exhibit fast electron transfer kinetics. Polyviologens have been commonly fabricated through step-growth polymerisation in linear and dendritic architectures,9–13 as supramolecular polymers,14–16 networks,6,17,18 and covalent organic frameworks.19,20 Alternatively, anionic/cationic or metathesis-based polymerisations are used to avoid interference of radical-stabilising monomers with the radical initiators, however, these techniques are highly water- and/or oxygen-sensitive.21,22 When free-radical polymerisation (FRP) is conducted in the presence of viologen species, its reduction can cause a depletion of active radicals and thus disruption of the polymerisation process. Despite varying solvents, comonomers and initiator loadings, the direct FRP of viologen-containing monomers remains therefore limited to molar masses of 30 kDa.23–25 Accessing higher molar masses has been possible via post-polymerisation modification,26–28 which has impacted the electrochemical properties of the resultant materials.29,30 Alternative strategies to access higher molar masses of redox-active polymers and control their polymerisation are highly desirable.Incorporation of cucurbit[n]uril (CB[n]) macrocycles have lead to a variety of functional materials through host–guest chemistry.31–34 Moreover, the redox chemistry of viologens can be modulated through complexation with CB[n].35–38 Specifically, CB[n] (n = 7, 8) can tune the redox potential of pristine viologens and efficiently sequester monoreduced viologen radical cations, avoiding precipitation in aqueous environments. Further to this, we recently demonstrated that the viologen radical cation is stabilised by −20 kcal mol−1 when encapsulated in CB[7].39Consequently, we envisioned that incorporating CB[n]s as additives prior to polymerisation could (i) overcome current limits in accessible molar masses, (ii) increase control over FRP of viologen-based monomers through encapsulation and (iii) enable separation of radical species avoiding aggregation.Here, we demonstrate a new approach to control FRP of redox-active monomers leading to high molar masses and decreased dispersity of the resultant polymers. In absence of CB[n], co-polymerisation of the N-styryl-N′-phenyl viologen monomer 12+ and N,N-dimethylacrylamide (DMAAm) only occurs at high initiator loadings (>0.5 mol%, Fig. 1a), leading to low molecular weights and high polydispersity. Using our synthetic approach, 12+ is efficiently copolymerised with DMAAm in the presence of CB[n] (n = 7, 8) macrocycles resulting in control of the polymer molar mass across a broad range, 4–500 kDa (Fig. 1b). Finally, CB[n] are successfully removed from the polymer via competitive host–guest binding and dialysis. Spectroscopic and electrochemical studies revealed that solubilisation/stabilisation of the reduced species and/or shielding of the redox-active monomers from electron transfer processes was responsible for this enhancement.Open in a separate windowFig. 1Schematic representation of the investigated polymerisation. (a) Conventional free radical polymerisation either completely fails to copolymerise redox-active monomers (low initiator loading) or delivers copolymers with limited molar masses and high dispersities (high initiator loading). (b) CB[n]-mediated protection suppresses interference of viologen monomers with radicals formed through the initiation process facilitating copolymerisation. The molar mass of the resulting copolymers is readily tunable via the amount of present CB[n] macrocycles and the CB[n] is post-synthetically removed via competitive binding to yield the final copolymer with desired molar mass. Cl− counter-ions are omitted for clarity.Recent studies on symmetric aryl viologens demonstrated 2 : 2 binding modes with CB[8] and high binding constants (up to Ka ∼ 1011 M−2).40,41 Incorporation of polymerisable vinyl moieties, in combination with the relatively static structure of their CB[n] host–guest complexes, was postulated to allow polymerisation without unfavorable side reactions. The asymmetric N-styryl-N′-phenyl viologen monomer 12+ prepared for this study (Fig. S1a and S2–S13†) displays a linear geometry and was predicted to bind CB[n] (n = 7, 8) in a 2 : 1 and 2 : 2 binding fashion (Fig. S1b†).40,42 Binding modes between CB[n] (n = 7, 8) and 12+ were investigated through titration experiments (1H NMR and ITC) which confirmed the formation of 1·(CB[7])2 and (1)2·(CB[8])2 (see Fig. S25 and S26†). 1H NMR titration of CB[7] with 12+ demonstrates encapsulation of both aryl moieties (including the vinyl group) through upfield chemical shifts of the respective signals (Fig. 2a). Similar upfield shifts were observed for CB[8] (Fig. 2c). Different para-aryl substituents (vinyl vs. hydrogen) resulted in either head-to-tail or head-to-head (1)2·(CB[8])2 dimers (Fig. S1b and S26†), a previously reported phenomenon.43 Nonetheless, the reversible nature of the complex renders the vinyl group temporarily available for copolymerisation. In the presence of CB[8], 12+ yields polymer molar masses of up to 500 kDa as its complexation is more robust. ITC data confirmed binding stoichiometry, with binding constants of Ka = 2.64 × 106 M−1 for 1·(CB[7])2 and Ka = 9.02 × 1010 M−2 for (1)2·(CB[8])2 (Table S2, Fig. S29a and b†).Open in a separate windowFig. 2Supramolecular complexation of 12+ and CB[n]. 1H NMR spectra of 12+ at (a) χCB[7] = 2, (b) χCB[n] = 0 and (c) χCB[8] = 1 in D2O. Cl− counter-ions are omitted for clarity.The free radical copolymerisation of 12+ and DMAAm ([M] = 2 M), in the absence of CB[n], was based on optimised DMAAm homopolymerisations (Fig. S14 and S15†) and full conversion was confirmed by 1H NMR spectroscopy (Table S1 and Fig. S16†). 12+ was maintained at 1 mol% relative to DMAAm and by varying the radical initiator concentration molar masses of up to 30 kDa with broad dispersities (Đ = 11.4) were obtained (Fig. S17†). Lower initiator concentrations (<0.25 mol%) limited polymerisation (Mn = 3.7 kDa) and size exclusion chromatography elution peaks exhibited extensive tailing, suggesting that 12+ engages in radical transfer processes.To verify our hypothesis that CB[n] macrocycles can modulate the redox behavior of 12+, FRP of 12+ and DMAAm was conducted with varying amounts of CB[n] (n = 7, 8) (Fig. 3, S18 and S20†). Full conversion of all monomers including their successful incorporation into the polymer was verified via1H NMR spectroscopy and SEC (Fig. S18 and S21–S23†). Using CB[7], the molar mass of the copolymers was tunable between Mn = 3.7–160 kDa (Fig. 3b and S21a†). Importantly, in the presence of CB[8], a broad range of molar masses Mn = 3.7–500 kDa were accessible for 0 < χCB[8] < 1.2 (Fig. S20 and S21b†). Increasing the CB[n] (n = 7, 8) concentration caused dispersity values to converge to Đ = 2.2 (χCB[8] = 1.2, χ is the ratio of CB[n] to the redox-active monomer, Fig. S20†). The copolymers were purified by addition of adamantylamine (competitive binder) prior to dialysis to deliver CB[n]-free redox-active copolymers (Fig. S23†).Open in a separate windowFig. 3(a) In situ copolymerisation of DMAAm with 12+ and CB[7]. (b) Molar mass and dispersity vs. amount of CB[7] in the system. Fitted curve is drawn to guide the eye. Cl− counter-ions are omitted for clarity.The range of molar masses obtainable through addition of CB[n] (n = 7, 8) correlated with the measured Ka (Fig. 3b and S20†). Binding of 12+ to CB[8] was stronger and therefore lower concentrations of CB[8] were required to shift the binding equilibrium and mitigate disruption of the polymerisation. Dispersity values reached a maximum at χCB[7] = 0.6 or χCB[8] = 0.3, suggesting 1+˙ is only partially encapsulated. Consequently, higher CB[n] concentrations can enable FRP with lower initiator concentrations (0.10 mol%, Fig. S19†), which demonstrates the major role of complexation to modulate electron accepting properties of 12+.The redox-active monomer 12+ can engage with propagating primary radicals (Pm˙) to either be incorporated into the growing polymer chain (Pm–12+˙) or to abstract an electron deactivating it (Pm). This deactivation likely occurs through oxidative termination producing 1+˙ (energetic sink), inactive oligo- and/or polymer chains (Pm) and a proton H+, causing retardation of the overall polymerisation. Oxidative terminations have been previously observed in aqueous polymerisations of methyl methacrylate, styrenes and acrylonitriles that make use of redox initiator systems.44–47 Another example by Das et al. investigated the use of methylene blue as a retarder, with the primary radical being transferred to a methylene blue electron acceptor via oxidative termination, altogether supporting the outlined mechanism of our system (extended discussion see ESI, Section 1.4†).48The process of retardation can, however, be successfully suppressed, when monomer 12+ is encapsulated within CB[n] macrocycles. Herein the formation of 1·(CB[7])2 or (1)2·(CB[8])2 results in shielding of the redox-active component of 12+ from other radicals within the system, hampering other electron transfer reactions. This inhibits termination and results in extended polymerisation processes leading to higher molar mass polymers through mitigation of radical transfer reactions. Moreover, suppressing the formation of 1+˙ through supramolecular encapsulation minimises both π and σ dimerisation of the emerging viologen radical species,39 preventing any further reactions that could impact the molar mass or polydispersity of the resulting polymers.Cyclic voltammetry (CV) and UV-Vis titration experiments were conducted to provide insight into the impact of CB[n] on the redox behavior and control over FRP of 12+. Excess of CB[n] (n = 7, 8) towards 12+ resulted in a complete suppression of electron transfer processes (Fig. S31 and S32†). Initially, 12+ shows a quasi-reversible reduction wave at −0.44 V forming 1+˙ (Fig. 4a). Increasing χCB[7], this reduction peak decreases and shifts towards more negative potentials (−0.51 V, χCB[7] = 1) accompanied by the formation of 12+·(CB[7])1. A second cathodic peak emerges at −0.75 V due to the increased formation of 12+·(CB[7])2. At χCB[7] = 2, this peak shifts to −0.80 V, where it reaches maximum intensity, once 12+·(CB[7])2 is the dominating species in solution. When 2 < χCB[7] < 4, the intensity of the reduction peak decreases and the complexation equilibrium is shifted towards the bound state, complete suppression of the reduction peak occurs at χCB[7] = 4. Similarly, the oxidation wave intensity is reduced by 95% at χCB[7] = 4 causing suppression of potential oxidative radical transfer processes (Fig. 4c).Open in a separate windowFig. 4Mechanism of the CB[n]-mediated (n = 7, 8) strategy for the controlled copolymerisation of redox-active monomer 12+. (a) Cyclic voltammogram with varying amounts of CB[7]. (b) UV-Vis titration of 12+ with varying amounts of CB[7]. (c) Intensity decay of the oxidation peak at −0.27 V and change in absorption maximum of 1+˙ at 590 nm vs. χCB[7]. (d) Electron transfer processes of 12+ to generate 1+˙ and 10. (e) Reduction of 12+ resulting in precipitation of 10. (f) Stabilisation of 1+˙ through encapsulation with CB[7]. (g) Protection of 12+ from redox processes through CB[7]-mediated encapsulation.The concentration of 1+˙ can be monitored using UV-Vis (Fig. 4b and S34†).49 Absorbance at 590 nm (λmax) vs. χCB[7] was plotted and the concentration of 1+˙ increases, reaching a maximum at χCB[7] = 4 (Fig. 4c). When χCB[7] > 4, a decrease in concentration of 1+˙ was observed. We postulate the following mechanism: at χCB[7] = 0, 12+ is reduced to produce high concentrations of 1+˙ that partially disproportionates to form 10, which precipitates (Fig. 4e and S34†). When 0 < χCB[7] < 4, increasing amounts of green 1+˙ are stabilised through encapsulation within CB[7] suppressing disproportionation (Fig. 4c (cuvette pictures), Fig. 4f). For χCB[7] > 4, 12+ is protected from reduction through encapsulation (Fig. 4g).To further demonstrate applicability of this strategy, we chose another viologen-based monomer 22+ for copolymerisation (Fig. 5a). As opposed to 12+, CB binds predominantly to the styryl moiety of 22+ (Fig. S27 and S28†).50 ITC data showed that 22+ binds CB[7] in a 1 : 1 fashion with a binding affinity of Ka = 2.32 × 106 M−1 (Fig. S30 and Table S2†). Monomer 22+ was also analysed via CV and showed three reversible reduction waves at −0.91 V, −0.61 V (viologen) and 0.40 V (styrene). Similar to 12+, excess CB[7] selectively protects the molecule from redox processes, while the vinyl moiety remains accessible (Fig. 5a, S33c and d†). For CB[8], only partial suppression of electron transfer processes was observed (Fig. S33e and f†). We therefore chose CB[7] as an additive to increase control over FRP of 22+ (Fig. 5b). Copolymerisation of 22+ (1 mol%) and DMAAm ([M] = 2 M) at χCB[7] = 0 resulted in Mn = 28 kDa. When χCB[7] = 0.1, 0.2 or 0.3, Mn increased gradually from 124 to 230 and 313 kDa, respectively, demonstrating the potential of this strategy for FRP of redox-active monomers. Higher percentages of CB[7] led to copolymers with presumably higher molar masses causing a drastic decrease in solubility that prevented further analysis. Investigations on a broader spectrum of such copolymers, including those with higher contents of 22+ are currently ongoing.Open in a separate windowFig. 5(a) Cyclic voltammogram of viologen-containing monomer 22+ and its complexation with CB[n] (n = 7, 8) at a concentration of 1 mM using a scan rate of 10 mV s−1 in 0.1 mM NaCl solution. (b) Molar mass and dispersity of 22+-containing copolymers vs. equivalents of CB[7]. Cl− counter-ions are omitted for clarity.In conclusion, we report a supramolecular strategy to induce control over the free radical polymerisation of redox-active building blocks, unlocking high molar masses and reducing polydispersity of the resulting polymers. Through the use of CB[n] macrocycles (n = 7, 8) for the copolymerisation of styrenic viologen 12+, a broad range of molar masses between 3.7–500 kDa becomes accessible. Our mechanistic investigations elucidated that the redox behavior of monomer 12+ is dominated by either CB[n]-mediated stabilisation of monoradical cationic species or protection of the encapsulated pyridinium species from reduction. In the stabilisation regime (χCB[7] < 4), 12+ is reduced to form the radical cation 1+˙, which is subsequently stabilised through CB[7] encapsulation. Upon reaching a critical concentration of CB[7] (χCB[7] > 4), the system enters a protection-dominated regime, where reduction of 12+ is suppressed and the concentration of 1+˙ diminishes. The resulting copolymers can be purified by use of a competitive binder to remove CB[n] macrocycles from the product. This strategy was successfully translated to a structurally different redox-active monomer that suffered similar limitations. We believe that the reported strategy of copolymerisation of redox-active monomers will open new avenues in the synthesis of functional materials for energy conversion and storage as well as for applications in electrochromic devices and (nano)electronics. 相似文献
4.
5.
Dr. Umesh A. Kshirsagar Regev Parnes Hagit Goldshtein Dr. Rivka Ofir Dr. Raz Zarivach Dr. Doron Pappo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(40):13575-13583
An iron‐based cross‐dehydrogenative coupling (CDC) approach was applied for the diversity‐oriented synthesis of coumestrol‐based selective estrogen receptor modulators (SERMs), representing the first application of CDC chemistry in natural product synthesis. The first stage of the two‐step synthesis of coumestrol involved a modified aerobic oxidative cross‐coupling between ethyl 2‐(2,4‐dimethoxybenzoyl)acetate and 3‐methoxyphenol, with FeCl3 (10 mol %) as the catalyst. The benzofuran coupling product was then subjected to sequential deprotection and lactonization steps, affording the natural product in 59 % overall yield. Based on this new methodology other coumestrol analogues were prepared, and their effects on the proliferation of the estrogen receptor (ER)‐dependent MCF‐7 and of the ER‐independent MDA‐MB‐231 breast cancer cells were tested. As a result, new types of estrogen receptor ligands having an acetamide group instead of the 9‐hydroxyl group of coumestrol were discovered. Both 9‐acetamido‐coumestrol and 8‐acetamidocoumestrol were found more active than the natural product against estrogen‐dependent MCF‐7 breast cancer cells, with IC50 values of 30 and 9 nM , respectively. 相似文献
6.
Sandberg RL Paul A Raymondson DA Hädrich S Gaudiosi DM Holtsnider J Tobey RI Cohen O Murnane MM Kapteyn HC Song C Miao J Liu Y Salmassi F 《Physical review letters》2007,99(9):098103
We present the first experimental demonstration of lensless diffractive imaging using coherent soft x rays generated by a tabletop soft-x-ray source. A 29 nm high harmonic beam illuminates an object, and the subsequent diffraction is collected on an x-ray CCD camera. High dynamic range diffraction patterns are obtained by taking multiple exposures while blocking small-angle diffraction using beam blocks of varying size. These patterns reconstruct to images with 214 nm resolution. This work demonstrates a practical tabletop lensless microscope that promises to find applications in materials science, nanoscience, and biology. 相似文献
7.
Shady Farah Oren Aviv Natalia Laout Stanislav Ratner Nurit Beyth Abraham J. Domb 《先进技术聚合物》2014,25(6):689-692
Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S‐QA‐PEI). The synthesized S‐QA‐PEI particles were identified with a slight particle size increase of 2–3 µm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, ?16.7 ± 5.11 mV, the prepared S‐QA‐PEI particles are positively charged, +50–60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
8.
Solitons in nonlinear media with an infinite range of nonlocality: first observation of coherent elliptic solitons and of vortex-ring solitons 总被引:2,自引:0,他引:2
We present an experimental study on wave propagation in highly nonlocal optically nonlinear media, for which far-away boundary conditions significantly affect the evolution of localized beams. As an example, we set the boundary conditions to be anisotropic and demonstrate the first experimental observation of coherent elliptic solitons. Furthermore, exploiting the natural ability of such nonlinearities to eliminate azimuthal instabilities, we perform the first observation of stable vortex-ring solitons. These features of highly nonlocal nonlinearities affected by far-away boundary conditions open new directions in nonlinear science by facilitating remote control over soliton propagation. 相似文献
9.
Various statistics on wreath products are defined via canonical words, “colored” right to left minima and “colored” descents.
It is shown that refined counts with respect to these statistics have nice recurrence formulas of binomial-Stirling type.
These extended Stirling numbers determine (via matrix inversion) dual systems, which are also shown to have combinatorial
realizations within the wreath product. The above setting also gives rise to a MacMahon-type equi-distribution theorem over
subsets with prescribed statistics.
Partially supported by Minerva Grant No. 8441 and by EC's IHRP Programme, within the Research Training Network “Algebraic
Combinatorics in Europe”, grant HPRN-CT-2001-00272.
Partially supported by EC's IHRP Programme, within the Research Training Network “Algebraic Combinatorics in Europe”, grant
HPRN-CT-2001-00272. 相似文献
10.
Amitai Regev 《Advances in Mathematics》1982,46(2):230-240
An asymptotic formula, involving integrals, is given for certain combinatorial sums. By evaluating a multi-integral it is then found that as n → ∞, the codimensions cn(F2) and the trace codimensions tn(F2) of F2, the 2 × 2 matrices, are asymptotically equal: . 相似文献