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Itsuro Matsuo Muneo Ohkido Hitoshi Fujita Kenshi Suzuki 《Photochemistry and photobiology》1980,31(2):175-178
Abstract— When a suspension of Escherichia coli was irradiated with near-UV light in the presence of chlorpromazine (at a concentration below a cytotoxic level), the cells were killed. Efficiency of the photodynamic killing was not influenced by the deficiency of the uvrA gene or the recA gene. Neither phenotypic reversion of E. coli Hs30R (arginine auxotroph) nor induction of lambda prophage in lysogenic bacteria was detected after this treatment. 相似文献
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Itsuro Matsuo Muneo Ohkido Hitoshi Fijita Kenshi Suzuki 《Photochemistry and photobiology》1980,31(2):169-173
Abstract— Both DNA bacteriophage and RNA bacteriophage were inactivated when they were irradiated with near-UV light (black light) in the presence of chlorpromazine. The far-UV sensitive mutants of T4D, i.e. T4D v , T4D px and T4D y , were no more sensitive to near-UV light plus chlorpromazine than the wild type. Electron microscopic observations showed that adsorption of T4D was greatly influenced by the treatment. The present results may indicate that the inactivation of T4D is due to the loss of adsorption caused by impairment in the tail or the tail fiber protein rather than the inactivation of DNA. 相似文献
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