Abstract Inorganic pyrophosphatase (EC 3. 6. 1. 1) drived the reaction of uridine 5′-triphosphate with glucose 1-monophosphate in the direction of uridine 5′-diphosphoglucose formation. 相似文献
Rapid separation of hydrophobic compounds such as bisindolylmaleimides, indolocarbazoles or fullerene C60 derivatives by ultra performance liquid chromatography was developed. Bisindolylmaleimides and indolocarbazoles were separated within 7 and 5 min, respectively. The linear ranges for the determination of bisindolylmaleimides and indolocarbazoles were 1.25?500 pmol and 0.5?50 pmol per injection (r > 0.99), respectively. Fullerene C60 derivatives were separated within 9 min, and the linear range for the determination of fullerene C60 derivatives was 0.1?10 pmol per injection (r > 0.99). 相似文献
A manifold is described which permits the analysis of less than 1 ml of sample solution. Water- and air-compensation methods for the introduction of the carrier stream into the nebulizer are effective in obtaining sensitive and reproducible measurements of magnesium, but air-compensation gives higher peak responses. 相似文献
A series of size‐controlled, cyclic poly(tetrahydrofuran)s ( of 4 400–8 600) that consist exclusively of the monomer, i.e., oxytetramethylene, unit ( I ) have been prepared in high yield through the metathesis polymer cyclization of a telechelic precursor having allyl groups, 1 , in the presence of a Grubbs catalyst, and the subsequent hydrogenation of the linking, i.e., 2‐butenoxy, unit in the presence of an Adams' catalyst (PtO2). A remarkable topology effect has subsequently been observed upon the isothermal crystallization of these two model polymers, showing distinctive spherulite growth rates and spherulite morphologies in comparison with the relevant linear poly(tetrahydrofuran) counterpart that has ethoxy end groups ( II ).
Computer simulation, using the molecular dynamics (MD) technique, has been carried out on amorphous silicon nitride (a-Si3N4) with simple Busing-type potentials. From the MD simulation, the following points have been deduced. (1) The average Si---N bond length obtained from MD results is rSi---N=1.74 Å, and its coordination number, NSi---N, is 3.95. The bond angles around a Si and a N atom, N---Si---N and Si---N---Si, are found to be 109.8° ± 12.36° and 127.08° ± 16.63°, respectively. The N---Si---N value obtained is in very good agreement with the tetrahedral bond angle (= 109.47°). Hence, the short-range structural arrangement of a-Si3N4 comprises tetrahedral SiN4 units. The MD results presented in this study also indicate that there exist only a small number of defects such as dangling bonds. (2) These MD results are in good agreement with the reported X-ray and neutron data. The a-Si3N4 structure can be reproduced by the MD simulation given in this study. 相似文献
The structure of Na2OGa2O3SiO2 glasses of four different compositions containing up to 45 mol. % Ga2O3 has been determined by the X-ray diffraction method. The radial distribution function D(r) obtained indicates that Ga3+ ions are in fourfold coordination and GaO4 tetrahedra are formed in these glasses. The reduced intensity function S·i(S) and radial distribution function D(r) which were calculated based on a structural model for A-25, 0.25(Ga2O3)·0.75(Na2O·2SiO2)/3 glass agreed well with the observed ones. 相似文献
We developed new intravenous sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. We synthesized approximately 170 derivatives and evaluated their hypnotic effects by intravenous administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs, 3(-), 5(-), 27(-), and 47(-) [JM-1232(-)], showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, respectively, and the lethal doses (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, respectively. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, respectively. Among these compound, 47(-) [JM-1232(-)] is being considered as the most potential candidate for clinical trials in humans. 相似文献
31P-NMR chemical shifts and coupling constants of nine inorganic phosphorus compounds composed of different structural units or oxidation numbers PV, PIV, PIII, and PI were measured in the pH-range 3 11. A concise map of NMR data providing the pH-dependence of the chemical shift (-pH map) was set up to be used for identifying phosphorus compounds under varying pH-conditions. Chemical shifts of monofluorophosphate, as well as most phosphorus compounds of oxidation numbers 5 and 4, were greatly dependent on pH, in contrast to the less or negligible pH-dependence of phosphorus compounds of oxidation numbers 1 and 3. Monofluorophosphate gave the parameters: =+1.3±0.2 ppm and 1JPF=870±0.2 Hz, that remained unchanged at pH>6, but varied at pH<6. The practical use of the -pH map was shown with a few kinetic experiments in which monofluorophosphate was enzymatically hydrolyzed by alkaline phosphatase (EC3.1.3.1) at pH 7.2 and non-enzymatically at pH 3. 相似文献
The Plankian radiation temperature of an intense x-ray source driven by imploding spherical CH plastic shell is measured with a filtered-multi-channel pinhole camera. With all the twelve laser beams of the GEKKO-XII laser facility applied, the average radiation temperature is measured to be around 465 eV while the temperature at the core is as high as 818eV. This value is confirmed by other instruments applied. 相似文献