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1.
2.
Nano titanium dioxide (nTiO2), generally considered to be toxicologically inert, is manufactured in large quantities and extensively applied in consumer products. The small size and large surface area endow them with an active group or intrinsic toxicity. Advances in instrumentation are making Raman spectroscopy the tool of choice for an increasing number of (bio) chemical applications. One of the great advantages of this technique is its ability to provide information on the concentration, structure and interaction of biochemical molecules in their microenvironments within intact cells and tissues, non-destructively. Zebrafish (Danio rerio), one of the most important vertebrate model organisms used in developmental biology, are increasingly used in biomedical research, particularly as a model of human disease. In the present work, an attempt is made to study the effect of titanium dioxide, both nano and bulk, on the microenvironment of the liver tissues of Zebrafish using FT-Raman spectroscopy. The results of the present study suggest that TiO2 exposure demonstrate a marked influence on the microenvironments of the liver tissues of Zebrafish. A shift to a higher wavenumber and an increase in the intensity of the band at ∼1087 cm−1 in the TiO2 exposed tissues suggest that some of the conformational changes resulting from the alkali recovery process takes place due to TiO2 exposure. The decreased intensity ratio (I3220/I3400) observed in the titanium-exposed tissues suggests a decreased water domain size, which could be interpreted in terms of weaker hydrogen-bonded molecular species of water in the TiO2 exposed tissues. The observed shift of COO− bands to higher frequencies shows the disruption of salt bridges as a result of a change in the oppositely charged partners and due to the enhanced random coil conformation. The variation in the intensity ratio of the tyrosyl doublet (I858/I825) indicates variation in the hydrogen bonding of the phenolic hydroxyl group due to TiO2 exposure. The results further suggest that the microenvironments are greatly altered due to titanium nano exposure when compared to titanium bulk. In conclusion, the results indicate that FT-Raman spectroscopy might be a useful tool for rapid assessment of nano particle biological interactions. 相似文献
3.
RD Harris WS Baker Van Stipdonk MJ RM Crooks EA Schweikert 《Rapid communications in mass spectrometry : RCM》1999,13(14):1374-1380
A suite of keV polyatomic or 'cluster' projectiles was used to bombard unoxidized and oxidized self-assembled monolayer surfaces. Negative secondary ion yields, collected at the limit of single ion impacts, were measured and compared for both molecular and fragment ions. In contrast to targets that are orders of magnitude thicker than the penetration range of the primary ions, secondary ion yields from polyatomic projectile impacts on self-assembled monolayers show little to no enhancement when compared with monatomic projectiles at the same velocity. This unusual trend is most likely due to the structural arrangement and bonding characteristics of the monolayer molecules with the Au(111). Copyright 1999 John Wiley & Sons, Ltd. 相似文献
4.
Subbiah Meenakshisundaram RM. Sockalingam 《Journal of molecular catalysis. A, Chemical》2000,160(2):269-275
Catalytic activity of Os(VIII) in the oxidation of some twenty organic sulfides with sodium salt of N-chlorobenzenesulfonamide (CAB) has been investigated in alkaline (pH8.7) t-butanol–water (1:1 v/v) medium. Significant retarding influence of [OH−] on the reactivity is exhibited. The catalysed reaction is strongly accelerated in the presence of Hg(II). Imperfections are observed in the linear Hammett relationship in the case of –NO2 substituents. 相似文献
5.
6.
The results of both experimental studies and molecular dynamics simulations indicate that crystals exhibit strong size effects
at the sub-micron scale. In experimental studies, the size effects are usually explained by strain gradients. By contrast,
atomistic simulations suggest that the yield strength depends on the size even without strain gradients and scales with the
sample size through a power relationship. Here we address these two different approaches to the size dependence of mechanical
properties. Results of uniaxial compression experiments on gold single crystals at the sub-micron scale, without significant
stress/strain gradients, are presented. The free-standing single-crystal Au cylinders are created by focused ion beam machining
and are subsequently compressed using a nanoindenter fitted with a diamond flat punch. Compressive stresses and strains, as
well as pillar stiffnesses, are determined from the test data. The experiments show that the flow stresses of these pillars
increase significantly with decreasing pillar diameter, reaching several GPa for the smallest pillars. These high strengths
appear to be controlled by dislocation starvation, which is unique to small crystals.
PACS 68.60.Bs
An erratum to this article is available at . 相似文献
7.
E.T. Lilleodden J.A. Zimmerman W.D. Nix 《Journal of the mechanics and physics of solids》2003,51(5):901-920
Nanoindentation experiments have shown that microstructural inhomogeneities across the surface of gold thin films lead to position-dependent nanoindentation behavior [Phys. Rev. B (2002), to be submitted]. The rationale for such behavior was based on the availability of dislocation sources at the grain boundary for initiating plasticity. In order to verify or refute this theory, a computational approach has been pursued. Here, a simulation study of the initial stages of indentation using the embedded atom method (EAM) is presented. First, the principles of the EAM are given, and a comparison is made between atomistic simulations and continuum models for elastic deformation. Then, the mechanism of dislocation nucleation in single crystalline gold is analyzed, and the effects of elastic anisotropy are considered. Finally, a systematic study of the indentation response in the proximity of a high angle, high sigma (low symmetry) grain boundary is presented; indentation behavior is simulated for varying indenter positions relative to the boundary. The results indicate that high angle grain boundaries are a ready source of dislocations in indentation-induced deformation. 相似文献
8.
The role of temporal fluctuations and systematic variations of interaural parameters in localization of sound sources in spatially distributed, nonstationary noise conditions was investigated. For this, Bayesian estimation was applied to interaural parameters calculated with physiologically plausible time and frequency resolution. Probability density functions (PDFs) of the interaural level differences (ILDs) and phase differences (IPDs) were estimated by measuring histograms for a directional sound source perturbed by several types of interfering noise at signal-to-noise ratios (SNRs) between -5 and +30 dB. A moment analysis of the PDFs reveals that the expected values shift and the standard deviations increase considerably with decreasing SNR, and that the PDFs have non-Gaussian shape at medium SNRs. A d' analysis of the PDFs indicates that elevation discrimination is possible even at low SNRs in the median plane by integrating information across frequency. Absolute sound localization was simulated by a Bayesian maximum a posteriori (MAP) procedure. The simulation is based on frequency integration of broadly tuned "detectors." Confusion patterns of real and estimated sound source directions are similar to those of human listeners. The results indicate that robust processing strategies are needed to exploit interaural parameters successfully in noise conditions due to their strong temporal fluctuations. 相似文献
9.
Alfredsson M Catlow CR Paulidou A Nix RM 《Chemical communications (Cambridge, England)》2002,(18):2128-2129
By performing first-principles Molecular Dynamics simulations at 300 K, we show that water dissociates on the A-La2O3(001) surface giving rise to one exclusive type of hydroxyl-group, which is associated with a surface reconstruction, incorporating an additional oxygen ion into the oxide subsurface, yielding a surface structure that is oxygen rich. 相似文献
10.
P. Möller J. R. Nix P. Armbruster S. Hofmann G. Münzenberg 《Zeitschrift für Physik A Hadrons and Nuclei》1997,359(3):251-255
Fusion barriers are calculated in a macroscopic-microscopic model for several cold-fusion heavy-ion reactions leading to heavy and superheavy elements. The results obtained in such a picture are very different from those obtained in a purely macroscopic model. For reactions on 208Pb targets, shell effects in the entrance channel result in fusion-barrier energies at the touching point that are only a few MeV higher than the ground state for compound systems near Z = 110. The entrance-channel fragment-shell effects remain far inside the touching point, almost to configurations only slightly more elongated than the ground-state configuration, where the fusion barrier has risen to about 10 MeV above the ground-state energy. Calculated single-particle level diagrams show that few level crossings occur until the peak in the fusion barrier very close to the ground-state shape is reached, which indicates that dissipation is negligible until very late in the fusion process. Whereas the fission valley in a macroscopic picture is several tens of MeV lower in energy than is the fusion valley, we find in the macroscopic-microscopic picture that the fission valley is only about 5 MeV lower than the fusion valley for cold-fusion reactions leading to compound systems near Z = 110. These results show that no significant “extra-extrapush” energy is needed to bring the system inside the fission saddle point and that the typical reaction energies for maximum cross section in heavy-element synthesis correspond to only a few MeV above the maximum in the fusion barrier. 相似文献