排序方式: 共有21条查询结果,搜索用时 15 毫秒
1.
Madhu Kumar Reddy Kandula Mohan Gundluru Bakthavatchala Reddy Nemallapudi Sravya Gundala Peddanna Kotha Grigory V. Zyryanov Sridevi Chadive Suresh Reddy Cirandur 《Journal of heterocyclic chemistry》2021,58(1):172-181
A novel series of piperazine-1,2,3-triazole bearing dimethyl(((2-(4-((1H-1,2,3-triazole-4-yl)methyl)piperazin-1-yl)ethylamino)(2-hydroxyaryl)methyl)phosphonate derivatives have been prepared via copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) (Click Reaction) and Schiff base reactions. The synthesized compounds were confirmed by spectral characterization (1H, 13C and 31P NMR, and mass). The title compounds were evaluated for in vitro alpha glucosidase enzyme inhibition and in vitro antioxidant activity using DPPH and H2O2 methods. 相似文献
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Bakthavatchala Reddy Nemallapudi Grigory V. Zyryanov Balakrishna Avula Mallikarjuna Reddy Guda Sravya Gundala 《Journal of heterocyclic chemistry》2019,56(12):3324-3332
An effective and suitable meglumine‐catalyzed high‐yielding process was considered and engaged for the synthesis of new bis(indolyl)methanes at ambient temperature under aqueous conditions. The catalytic reaction proceeds very smoothly. Clean reaction, ease of product isolation/purification, easily available reactant and ecofriendly reaction conditions are the notable advantages of the present methodology. All the title compounds were characterized by IR, 1H, 13C NMR, and mass spectra. All the synthesized compounds were tested for antimicrobial activity, and the results indicated that most of the synthesized compounds exhibited excellent activity against the tested microorganisms. In this new series, compound 3l , having nitro substituent on the aromatic ring, showed exceptional potent inhibitory activity against Pseudomonas aeruginosa and Penicillium chrysogenum. 相似文献
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Kandula Madhu Kumar Reddy Shaik Mahammad Sadik Nagaripati Saichaithanya Kotha Peddanna Nemallapudi Bakthavatchala Reddy Gundala Sravya Zyryanov Grigory V Cirandur Suresh Reddy 《Research on Chemical Intermediates》2017,43(12):7087-7103
A novel series of α-aminophosphonates containing the trifluoromethyl aniline moiety were obtained in high yields by condensation of 2-methyl-3-trifluoromethyl aniline, aryl/heteroaryl aldehydes and dimethylphosphite in the presence of chitosan as a catalyst. The molecular modeling studies revealed their important structural features of binding affinities towards the target enzyme. The cytotoxicity of these compounds was evaluated against PC-3(prostate cancer), MCF-7 (breast cancer), HeLa(cCervix Cancer), U973, K562 and HL60 human lLeukemia cell lines. Compound 4k with a pyrene moiety showed high potency against a breast cancer cell line, while compounds 4g and 4k exhibited more promising cytotoxicity against U973, K562 and HL60 cell lines. 相似文献
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Reddy Vemulapati Hanuman Kumari Avula Krishna Reddy Guda Mallikarjuna Reddy Yellala Venkata Rami Garcia Jarem Raul Zyryanov Grigory V. Reddy Nemallapudi Bakthavatchala Rammohan Aluru 《Chemistry of Heterocyclic Compounds》2019,55(1):60-65
Chemistry of Heterocyclic Compounds - Environmentally benign one-pot multicomponent synthesis of different 1,4-dihydropyridine derivatives using montmorillonite K10 has been achieved. The... 相似文献
6.
Nemallapudi Bakthavatchala Reddy Grigory V. Zyryanov Guda Mallikarjuna Reddy Avula Balakrishna Adivireddy Padmaja Venkatapuram Padmavathi Cirandur Suresh Reddy Jarem Raul Garcia Gundala Sravya 《Journal of heterocyclic chemistry》2019,56(2):589-596
A new class of bis heterocycles‐benzimidazolyl pyrazoles were prepared from the Michael acceptor (E)‐3‐(1H‐benzimidazol‐2‐yl)‐1‐aryl‐prop‐2‐en‐1‐one. The thiamide group was exploited to develop thiazole ring on treatment with p‐fluorophenacyl bromide to get tris heterocycles. All the lead compounds were tested for antimicrobial activity. The compound 7d having nitro substituent on the aromatic ring showed greater antimicrobial activity particularly against Pseudomonas aeruginosa and Penicillium chrysogenum. 相似文献
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Aluru Rammohan Guda Mallikarjuna Reddy Jarem Raul Garcia Grigory V. Zyryanov Gundala Sravya Nemallapudi Bakthavatchala Reddy Gutha Yuvaraja 《Journal of heterocyclic chemistry》2019,56(2):470-476
A series of N‐substituted maleimide derivatives have been developed via acetic acid‐mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H2O2 methods. Compounds 5h and 5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions 5h and 5m generally show beneficial activity than electron capture substitution cores. Thus, compounds 5h and 5m may be useful as an exogenous antioxidant. 相似文献
8.
M Rajasekhar KU Maheswara Rao CS Sundar NB Reddy SK Nayak CS Reddy 《Chemical & pharmaceutical bulletin》2012,60(7):854-858
A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity. 相似文献
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Kunda UM Balam SK Nemallapudi BR Chereddy SS Nayak SK Cirandur SR 《Chemical & pharmaceutical bulletin》2012,60(1):104-109
A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are characterized by IR, (1)H-, (13)C-, (31)P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity. 相似文献
10.
Kandula Madhu Kumar Reddy Kotha Peddanna Mavallur Varalakshmi Nemallapudi Bakthavatchala Reddy Gundala Sravya Grigory V. Zyryanov 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):812-819
AbstractA simple and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting functionalized tetrahydropyridine phosphonate derivatives has been developed based on low-cost and environmentally benign ceric ammonium nitrate (CAN) catalyst via tandem reactions of 1,3-dicarbonyl compounds, diethylphosphoramidate and various aromatic aldehydes in acetonitrile at room temperature. High atom economy, good yields, eco-friendliness and mild reaction conditions are some of the important features of this protocol. 相似文献