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Subramanian Ganesa Sundararajan Karthik Arumugam Baliga Ashok Musmade Prashant Kini Suvarna 《平面色谱法杂志一现代薄层色谱法》2009,22(4):273-276
JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, accurate, precise, and specific high-performance thinlayer chromatographic (HPTLC) method for analysis of bicalutamide... 相似文献
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Maheshwari Gourab Subramanian Ganesa Sundararajan Karthik Arumugam Ranjithkumar Averineni Ginjupalli Prashant Musmade Kishore Udupa Nayanabhirama 《平面色谱法杂志一现代薄层色谱法》2007,20(5):335-339
JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, accurate, precise, and stability-indicating high-performance thin-layer chromatographic method has been established... 相似文献
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A simple and sensitive high-performance liquid chromatographic (HPLC) method was developed for quantification of aceclofenac in rat plasma. Ibuprofen was used as an internal standard (IS). The present method used protein precipitation for extraction of aceclofenac from rat plasma. Separation was carried out on reversed-phase C18 column (250 mm × 4.6 mm, 5 μ) and the column effluent was monitored by UV detector at 282 nm. The mobile phase used was methanol-triethylamine (pH 7.0; 0.3% v/v in Milli-Q water) (60:40%, v/v) at a flow rate of 1.0 mL min−1. This method was linear over the range of 50.0-3500.0 ng mL−1 with regression coefficient greater than 0.99. The mean recovery of aceclofenac and IS were 84.62 ± 3.23 and 89.19 ± 1.57%, respectively and the method was found to be precise, accurate, and specific during the study. The method was successfully applied for pharmacokinetic study of aceclofenac in rats. 相似文献
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A sensitive high performance liquid chromatographic (HPLC) method involving fluorescence detection was developed for the determination of fexofenadine (FEX), known to have low oral bioavailability, in rat plasma. In order to understand the effect of various chromatographic factors on the separation of analytes and to simultaneously optimize the resolution and analysis run time, a response surface method was used. The chromatographic separation was achieved using a Supelco C(18)-DB (250 mm x 4.6mm I.D./5 microm particle size) column with mobile phase comprising of ammonium acetate buffer and acetonitrile (63:37, v/v), delivered isocratically at a flow rate of 1.0 mL min(-1). Diphenhydramine was used as an internal standard (I.S.). The statistical evaluation of the method was examined and the method was found to be precise and accurate with a linearity range of 1-500 ng mL(-1) (r>0.9980). The intra- and inter-day precision studies showed good reproducibility with coefficients of variation (C.V.) less than 12.26%. The advantages of our method are small sample volume (100 microL), short time of analysis (13 min) and a simple sample extraction and clean-up as compared to the previously published methods. The established method provides a reliable bioanalytical methodology to carry out FEX pharmacokinetics in rat plasma. 相似文献
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