Synthesis of complexes of N-vinylpyrrolidone–vinylamine or N-vinylpyrrolidone–allylamine containing macrocyclic polyligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) with gallium-68 isotope and estimation of their in vivo distribution

Russian Chemical Bulletin - A method for radiolabeling the water-soluble N-vinylpyrrolidone copolymers with N-vinyl- and N-allylamine containing bifunctional chelation unit...     

Mixed-ligand complexes of N-vinylpyrrolidone/N-vinylformamide/N-vinyl iminodiacedic acid copolymers and diethyldithiocarbamate as a co-ligand with indium/indium-111

Mixed-ligand metal-polymer complexes (MPC) of N-vinylpyrrolidone-N-vinylformamide-N-vinyl iminodiacedic acid (VP-VFA-VIDA) copolymers and diethyldithiocarbamate (DEDTC) as a co-ligand with indium were synthesized under mild conditions and pH close to physiological values. Isolated MPC were characterized by UV, IR, ¹H NMR, atomic absorption spectrophotometry, and HPLC. The obtained data implied that the MPC contain 8–10?wt% of (IDA)In(DEDTC) fragments. The optimal conditions for radiochemical synthesis of VP-VFA-VIDA-¹¹¹In-(DEDTC) metal-polymer complex with mixed ligands were defined. The closest coordination environment of ¹¹¹In was studied by perturbed angular correlation technique. The obtained data are in good agreement with the information about weight amounts of the corresponding indium MPC.