Synthesis and biological activity of certain amino-derivatives of 5α-steroids

Certain 17β-aminoderivatives of 5α-steroids based on tigogenin were synthesized and their antitumor activity was studied. The structures of the synthesized compounds were confirmed by NMR and IR spectroscopy and mass spectrometry. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 263–265, May–June, 2006.     

Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from Stems of <Emphasis Type="Italic">Symphytum asperum</Emphasis> and <Emphasis Type="Italic">S. caucasicum</Emphasis>

Two high-molecular-weight (>1000 kDa) water-soluble preparations were isolated from stems of Symphytum asperum and S. caucasicum. Their basic component was established as poly[hydroxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], analogous to that of high-molecular-weight (>1000 kDa) preparations from roots of these same plants, using IR and NMR spectral data. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 303–305, July–August, 2005. An erratum to this article is available at .     

Synthesis and Antiviral Activity of Modified 5α-Steroids

Chemistry of Natural Compounds -     

Synthesis and antituberculosis activity of certain steroidal derivatives of the 5<Emphasis Type="Italic">α</Emphasis>-series

The antituberculosis activity of several steroidal compounds of various structure was studied. Severa compounds that were active toward M. tuberculosis were found in in vitro tests. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 500–501, September-October, 2008. Original article submitted July 10, 2008.     

Synthesis and antimycobacterial activity of some steroidal derivatives of tigogenin

Some 5α-type steroidal derivatives of the steroidal sapogenin tigogenin were synthesized. The structures of the synthesized derivatives were characterized by spectral methods and elemental analysis. The antituberculosis activity of the compounds toward Mycobacterium tuberculosis strain H37Rv was studied in vitro (Microplate Alamar Blue Assay) in BACTEC 12B medium and was compared with that of isoniazide. Some of the synthesized compounds exhibited high (92-98%) antimycobacterial activity. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 332-334, May-June, 2009.     

Synthesis and Cytotoxic Activity of 5α-Pregnanolone Hydrazones

Chemistry of Natural Compounds -