Metabolites of Artemisia juncea and their Effect on Regulation of Thymocyte Volume

Chemistry of Natural Compounds -     

A new melampolide and other secondary metabolites from <Emphasis Type="Italic">Artemisia baldshuanica</Emphasis>

The composition of secondary metabolites in benzene and alcohol extracts of the epigeal part of Artemisia baldshuanica Krasch. et Zarp. (Asteraceae) collected during the vegetative phase was investigated. A new melampolide, the structure of which was established based on spectral data and an x-ray crystal structure analysis, and known compounds were isolated.     

Flavone glucosides from Artemisia juncea

A new flavone glucoside, 4′,5-dihydroxy-3′,5′,6-trimethoxyflavone-7-O-β-D-glucoside was obtained from aerial parts of Artemisia juncea, together with the known flavone eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of A. juncea showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl₃ fraction.     

New flavanone and other constituents of <Emphasis Type="Italic">Helichrysum arenarium</Emphasis> indigenous to China

A new flavonoid for which the structure (2S)-5,8,4'-trihydroxy-6,7-vinylenedioxyflavanone was established and the known compounds stigmasterol, stigmasterol β-D-glucopyranoside, caffeic acid ethyl ester, and 3,4-methylenedioxycinnamic acid were isolated from Helichrysum arenarium.     

Eudesmanolides from <Emphasis Type="Italic">Artemisia lehmanniana</Emphasis>. Crystal and molecular structures of 1α-acetoxy-4α-hydroxy-5,7α,6,11β(H)-eudesm-2,3-en-,12-olide and 1α-acetoxy-3α-hydroxy-5,7α,6,11β(H)-eudesm-4,15-en-6,12-olide

Two eudesmane sesquiterpene lactones of composition C₁₇H₂₄O₅ were isolated from the aerial part of Artemisia lehmanniana Bunge. X-ray structure analysis established their crystal and molecular structures.Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 458–460, November–December, 2004.This revised version was published online in April 2005 with a corrected cover date.     

9β-hydroxy-11β(H),13-dihyhdrosantamarine, a new eudesmanolide fromArtemisia leucotricha

A new sesquiterpene lactone, 9-hydroxy-11(H),13-dihydrosantamarine, and known terpenes are isolated from the underground part ofArtemisia leucotricha Krasch ex Ladyg (Asteraceae). The structure is determined by spectral and x-ray structural analysis.Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 230–232, May–June, 2000.     

1α-Acetoxy-11β(H),13-dihydrodouglanin, a New Eudesmanolide from Artemisia lehmanniana

A new sesquiterpene lactone, 1-acetoxy-11(H),13-dihydrodouglanin, was isolated fromArtemisia lehmanniana.The structure was established by spectral data and an x-ray analysis.