排序方式: 共有54条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Stanley Chang Dr. Michael Holmes Dr. Jeffrey Mowat Michael Meanwell Prof. Robert Britton 《Angewandte Chemie (International ed. in English)》2017,56(3):748-752
α-Arylcyclobutanones display unique reactivity that makes them valuable synthetic intermediates and target molecules. We describe the preparation of α-aryl- and α-heteroarylcyclobutanones through a direct α-arylation reaction. Problematic fragmentations are avoided by the use of LiOtBu, which promotes a rapid but reversible self-aldol reaction that slowly releases the enolate required for α-arylation. We also demonstrate the ring expansion of α-arylcyclobutanones, a process that is highlighted in the stereoselective synthesis of 1-methoxy coniothyrinone D. 相似文献
9.
10.
Molinaro C Mowat J Gosselin F O'Shea PD Marcoux JF Angelaud R Davies IW 《The Journal of organic chemistry》2007,72(5):1856-1858
We report herein a simple, scalable, transition-metal-free approach to the synthesis of alpha-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one. 相似文献