Calix[4]arene-Based Triple-Stranded Metallohelicate in Water

The title complex is a triple-stranded metallohelicate organized by the self-assembly of 5,17-difunctionalized calix[4]arenes and metal cations with octahedral coordination geometry. Due to hydrophilic triethylene glycol chains on the lower rim of the calix[4]arene, the metallohelicate can encapsulate cationic guests in water. NMR and UV-vis titration experiments reveal that the metallohelicate captures a pyridinium guest with an alanine derivative to form a host-guest complex with a host-guest ratio of 1 : 1. CD spectroscopy confirms the bias of the P- and M-helical sense of the metallohelicate by the captured guest. The metallohelicate captures two molecules of dicationic N,N’-dimethyl-DABCO and monocationic N-methyl quinuclidine, exhibiting a positive allosteric effect. ¹H NMR titration experiments indicate that the bound guests are in close proximately to the aromatic rings of the ligands. Molecular mechanics calculations based on the UV-vis and NMR observations suggest that the first guest preorganizes the conformation of the metallohelicate to facilitate access of the second guest to the cavity.     

Spektrophotometrische Bestimmung von Gleitmitteln, welche oberfl?chenaktive Stoffe auf der Basis von Polyoxy?thylen enthalten

Ohne Zusammenfassung     

Transient behavior of secondary emission of ZnTe under band-to-band excitation

Time characteristics of secondary emissions have been measured in ZnTe at 82K under the excitation into the fundamental absorption band by subnanosecond light pulses. The decay time of polariton luminescence has been determined to be about 100 ps. On the other hand, the time behavior of the intensity of the sharp 2LO-phonon line has been found to coincide with that of the exciting pulse. This result is consistent with the resonance Raman scattering mechanism.     

Determination of nitrate and nitrite in mixtures with a nitrate ion electrode

A rapid method for the determination of nitrate and nitrite ions is described. The potential of a mixture of nitrate and nitrite was measured with a nitrate ion selective electrode. The nitrite in the mixture is then oxidized to nitrate with permanganate in acid solution, and the potential of the oxidized solution is also measured with the electrode. The fundamental equations for the response of the nitrate ion electrode to nitrate ion in the presence of interfering ions were used, and a new equation was developed for calculating the original nitrate concentration of the mixture. The absolute errors for solutions of known concentrations (2.5–100 p.p.m. each) were 1.8 p.p.m. nitrate and 2 p.p.m. nitrite. When the results are calculated by computer, five determinations can be performed in 30 min. The method was applied to the determination of the oxides of nitrogen in cigarette smoke as nitrite and nitrate after dissolution in basic solution.     

Quantum-dot structures measuring Hamming distance for associative memories

Two types of quantum-dot circuits measuring a Hamming distance using the Coulomb repulsion effect are proposed and analysed. They have structures where a quantum-dot array is arranged on a gate electrode of an ultrasmall MOSFET. The device parameters for successful operation are clarified from Monte Carlo simulation.     

Determination of aluminum and iron by solvent extraction and gas chromatography

A method which combines solvent extraction and gas chromatography for the determination of aluminum and iron in the same sample is given. The two metals were extracted into benzene with trifluoroacetylacetone and a portion of the benzene layer was injected into a gas Chromatograph. The two chelates gave well resolved symmetrical peaks. The method was tested by analyzing a National Bureau of Standards alloy, number 162A. Copper and nickel, which would normally interfere when present in large amounts, were masked with picolinic acid. In addition a solvent extraction separation of iron from aluminum and a spectrophotometric determination of iron is described.     

Global Asymptotic Stability for Oscillators with Superlinear Damping

A necessary and sufficient condition is established for the equilibrium of the damped superlinear oscillator $$x^{\prime\prime} + a(t)\phi_q(x^{\prime}) + \omega^2x = 0$$ to be globally asymptotically stable. The obtained criterion is judged by whether the integral of a particular solution of the first-order nonlinear differential equation $$u^{\prime} + \omega^{q-2}a(t)\phi_q(u) + 1 = 0$$ is divergent or convergent. Since this nonlinear differential equation cannot be solved in general, it can be said that the presented result is expressed by an implicit condition. Explicit sufficient conditions and explicit necessary conditions are also given for the equilibrium of the damped superlinear oscillator to be globally attractive. Moreover, it is proved that a certain growth condition of a(t) guarantees the global asymptotic stability for the equilibrium of the damped superlinear oscillator.     

Novel benzamides as selective and potent gastrokinetic agents. IV. Synthesis and structure-activity relationships of 2-substituted 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides.

A new series of 2-substituted 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides (4-39) including a few 4-fluorobenzyl analogues were prepared and evaluated for their gastrokinetic activity by determining their effects on the gastric emptying activity of phenol red semisolid meal in rats. The C-2 substituent comprises alkoxy and variously substituted alkoxy groups. Among the derivatives, 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-2-(n-butoxy)-5-chlorobenza mide (5), its 4-fluorobenzyl (6), and 3-methyl-2-butenyloxy analogues (22) were superior to cisapride and essentially equipotent to the 2-ethoxy analogue (1b, AS-4370 as its citrate) in gastrokinetic activity. These compounds, like AS-4370, had no dopamine D2 receptor antagonistic activity.     

Synthesis of polyfunctionalized pyrroles bearing C-2 α-azido side-chains and displacement of the α-azido group by various nucleophiles

Tetrasubstituted pyrroles bearing C-2 α-azido side-chains were synthesized employing a new class of diazides, α,γ-diazido α,β-unsaturated esters, and 1,3-dicarbonyl compounds under simple thermal conditions. Further investigation of the synthetic utility of the obtained pyrroles reveals unexpected displacement of the α-azido group at the C-2 side-chain by a variety of nucleophiles. This two-step process exhibits a broad substrate scope, good functional group tolerance, simple operation, and high reaction efficiency, providing an easy access to polyfunctional pyrroles with novel substitution patterns.