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1.
A. R. Jalilian L. Mirsadeghi R. Haji-Hosseini 《Journal of Radioanalytical and Nuclear Chemistry》2007,274(1):175-179
Rituximab was successively labeled with [67Ga]-gallium chloride after residulation with freshly prepared cyclic DTPA-dianhydride. The best results of the conjugation
were obtained by the addition of 1 ml of a rituximab pharmaceutical solution (5 mg/ml, in phosphate buffer, pH 8) to a glass
tube pre-coated with DTPA-dianhydride (0.01 mg) at 25 °C with continuous mild stirring for 30 minutes. Radio thin-layer chromatography
showed an overall radiochemical purity of 96–99% at optimized conditions (specific activity = 300–500 MBq/mg, labeling efficiency
77%). The final isotonic 67Ga-DTPA-rituximab complex was checked by gel electrophoresis for radiolysis control. Radio-TLC was performed to ensure the
formation of only one species, followed by filtration through a 0.22 μm filter. Preliminary in vivo studies in normal rat
model was performed to determine the biodistribution of the radioimmunoconjugate up to 6 hours. 相似文献
2.
The main oral drug absorption barriers are fluid cell membranes, and generally drugs are absorbed by a passive diffusion mechanism. On the other hand, the blood–brain barrier (BBB) is considered to be the main barrier to drug transport into the central nervous system (CNS). The BBB restricts the passive diffusion of many drugs from blood to brain. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases in adequate experimental conditions, can be useful as an in vitro system in mimicking the drug partitioning process into biological systems. In this study, relationships between the BMC retention data of a heterogeneous set of 12 drugs and their pharmacokinetics parameters (human oral drug absorption and BBB penetration ability) are studied and the predictive ability of the models is evaluated. Modeling of log k BMC of these compounds was established by multiple linear regression in two different concentrations (0.07 and 0.09 M) of sodium dodecyl sulfate (SDS). The results showed a fair correlation between human oral drug absorption and BMC retention data in 0.09 M SDS (R 2 = 0.864) and a good correlation between the blood–brain distribution coefficient and BMC retention data in 0.07 M of SDS (R 2 = 0.887). Application of the developed models to a prediction set demonstrated that the model is also reliable with good predictive accuracy. The external and internal validation results showed that the predicted values are in good agreement with the experimental value. 相似文献
3.
Yousef Fazaeli Amir R. Jalilian Mostafa M. Amini Mohammadreza Aboudzadeh Shahzad Feizi Ali Rahiminezhad Kamran Yousefi 《Journal of Radioanalytical and Nuclear Chemistry》2013,295(1):255-263
Cu-64 was produced via the 68Zn (p,αn)64Cu nuclear reaction (≈200 mCi, >95 % chemical yield at 180 μA for 1.1 h irradiation, (radionuclidic purity >96 %, copper-67 as impurity) followed by purification with amino functionalized nano magnetic oxide, Fe3O4 aiming to remove trace amount of heavy metal ions from aqueous media due to achieve ultra pure [64Cu] CuCl2 for labeling step. [64Cu] labeled 5,10,15,20-tetrakis(penta fluoro phenyl) porphyrin ([64Cu]-TFPP) was prepared using freshly prepared [64Cu] CuCl2 (Cu-64; T 1/2 = 12.7 h) and 5,10,15,20-tetrakis(penta fluoro phenyl)porphyrin (H2TFPP) for 60 min at 100 °C under reflux condition (radiochemical purity: >97 % ITLC, >98 % HPLC, specific activity: 14–16 GBq/mmol). Stability of the complex was checked in final formulation and human serum for 24 h. The partition coefficient was calculated for the compound (log P = 0.73). The biodistribution of the labeled compound in vital organs of wild-type rats was studied using scarification studies and PET imaging up in 2 and 4 h after injection. A detailed comparative pharmacokinetic study performed for 64Cu cation and [64Cu]-TFPP. The complex is mostly washed out from the circulation through kidneys and liver and can be an interesting tumor imaging/targeting agent due to high specific uptake and rapid excretion through the urinary tract. 相似文献
4.
Nasim Vahidfar Amir R. Jalilian Yousef Fazaeli Ali Bahrami-Samani Davood Beiki Ali Khalaj 《Journal of Radioanalytical and Nuclear Chemistry》2014,301(1):269-276
166Ho labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin, and 5,10,15,20-tetrakis(3,4,5-trimethoxyphenyl) porphyrin ([166Ho]–TDMPP and [166Ho]–TTMPP respectively) were prepared with acceptable radiochemical purity and specific activities. Stability and partition coefficient of the complexes were determined in the final formulations and biodistribution studies in mouse demonstrated high accumulation of [166Ho]–TDMPP in the lung and liver and less excretion through the kidney. while [166Ho]–TTMPP was mostly excreted into intestines and kidneys while lungs were a minor accumulation site. In contrast to other reported radiolanthanide labeled porphyrins these two complexes showed less liver accumulation. Further investigation of their potential therapeutic properties is of interest. 相似文献
5.
6.
Fan Y Honarvar F Sinclair AN Jafari MR 《The Journal of the Acoustical Society of America》2003,113(1):102-113
When an immersed solid elastic cylinder is insonified by an obliquely incident plane acoustic wave, some of the resonance modes of the cylinder are excited. These modes are directly related to the incidence angle of the insonifying wave. In this paper, the circumferential resonance modes of such immersed elastic cylinders are studied over a large range of incidence angles and frequencies and physical explanations are presented for singular features of the frequency-incidence angle plots. These features include the pairing of one axially guided mode with each transverse whispering gallery mode, the appearance of an anomalous pseudo-Rayleigh in the cylinder at incidence angles greater than the Rayleigh angle, and distortional effects of the longitudinal whispering gallery modes on the entire resonance spectrum of the cylinder. The physical explanations are derived from Resonance Scattering Theory (RST), which is employed to determine the interior displacement field of the cylinder and its dependence on insonification angle. 相似文献
7.
A. R. Jalilian J. Garousi M. Akhlaghi P. Rowshanfarzad 《Journal of Radioanalytical and Nuclear Chemistry》2009,279(3):791-796
In order to target insulin receptors in various diabetic and insulinoma conditions, human recombinant insulin was successively
labeled with [111In]-indium chloride after conjugation with freshly prepared cyclic DTPA-dianhydride (ccDTPA). The best results of the conjugation
were obtained by addition of 0.5 mL of an insulin pharmaceutical solution (5 mg/mL, in phosphate buffer, pH 8) to a glass
tube pre-coated with DTPA-dianhydride (0.01 mg) at 25 °C with continuous mild stirring for 30 minutes. Radio-thin layer chromatography
(RTLC), instant thin layer chromatography (ITLC) and high performance liquid chromatography (HPLC) have shown an overall radiochemical
purity of higher than 93% at optimized conditions (specific activity = 550–750 MBq/mg, radiochemical yield =81%). The white
blood cell labeling capacity of the tracer was determined up to 4 hours at 37 °C. Preliminary in vivo studies in normal rat
model was performed to determine the biodistribution of the radiotracer up to 48 hours. It showed a high liver and spleen
uptake of the tracer which is consistent with other reported radiolabeled insulins. SPECT images have also shown high liver
accumulation of the tracer. 相似文献
8.
In this paper, the well known He’s variational iteration method (VIM) is used to construct solitary wave solutions for Boussinesq equation (BE). The chosen initial solution (trial function) can be in soliton form with some unknown parameters which can be determined in the solution procedure. 相似文献
9.
Ehsan Jalilian Sven Lidin 《Acta Crystallographica. Section C, Structural Chemistry》2010,66(8):m227-m230
The title compound, {(C14H16P)[Cu5I6]}n, prepared from the reaction between copper powder, iodine and dimethyldiphenylphosphonium iodide in hydroxyacetone, features an anion that consists of a continuous two‐dimensional Cu–I sheet [Cu—I = 2.5960 (14)–2.6994 (13) Å and Cu—I—Cu = 63.28 (5)–114.25 (5)°]. The cation, which lies on a mirror plane, is a typical dimethyldiphenylphosphonium ion. The structure shows a strong tendency towards segregation of the inorganic and organic parts of the structure into separate subspaces. The two‐dimensional Cu–I sheet displays a pronounced subcell with pseudo‐tetragonal symmetry that is broken by ordered vacancies on the Cu position. The symmetry is further reduced by the orientation of the interleaved organic counter‐ion that is inclined with respect to the pseudo‐mirror planes defined by the Cu–I sheet normal, perpendicular to the b axis. 相似文献
10.
Amir Reza Jalilian Mahdokht Jouiaei Alireza Doroudi Javad Garousi Sedigheh Moradkhani 《Journal of Radioanalytical and Nuclear Chemistry》2010,285(3):555-561
In this work, recently prepared 67Ga-labeled glucagon (67Ga-DTPA-GCG) for imaging studies (radiochemical purity >94%; HPLC, S.A. 296–370 GBq/mM) was used in biological studies. The wild-type rat biodistribution results, 2 h post injection, demonstrated high tissue:muscle ratios for target tissues (liver, kidney, heart, spleen, fat intestine stomach and pancreas), 234, 18.45, 7.12, 1.75, 128.7, 4.9, 6.3 and 1.11, respectively. The tracer binding capacity using freshly prepared rat brain homogenate demonstrated significant specific binding of the tracer to neuronal GCG receptors (67Ga-DTPA-GCG/67Ga:3 and 67Ga-DTPA-GCG/67GaDTPA:2.2 at 90 min). SPECT images also demonstrated target specific binding of the tracer at 4 h. The data suggests the tracer is accumulated in GCGR rich tissues 2–4 h post injection, suggesting potentials of the tracer for future imaging studies in glocagonoma models. 相似文献