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A one-step procedure was developed for the synthesis of new 6-fluoro-7-(isoxazolidin-2-yl)-4-oxo-1,4-dihydroquinolines. The procedure is based on the 1,3-dipolar cycloaddition of the azomethine oxide and 1,1-disubstituted alkenes, which are generated in situ from 6-fluoro-7-hydroxylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and CH-active compounds (dialkyl malonates, ethyl acetoacetate), respectively, in the presence of formaldehyde at 100—120 °C. 相似文献
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Nosova Emiliya V. Batanova Olga A. Mochulskaya Nataliya N. Charushin Valery N. 《Chemistry of Heterocyclic Compounds》2019,55(6):578-582
Chemistry of Heterocyclic Compounds - We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial... 相似文献
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Ramil F. Fatykhov Igor A. Khalymbadzha Ainur D. Sharapov Anastasia P. Potapova Nataliya N. Mochulskaya Anton N. Tsmokalyuk Alexandra V. Ivoilova Polina N. Mozharovskaia Sougata Santra Oleg N. Chupakhin 《Molecules (Basel, Switzerland)》2022,27(20)
A different type of MnO2-induced oxidative cyclization of dihydrotriazines has been developed. These dihydrotriazines are considered as a “formal” Schiff’s base. This method provided easy access to naphthofuro-fused triazine via the C-C/C-O oxidative coupling reaction. The reaction sequence comprised the nucleophilic addition of 2-naphthol or phenol to 1,2,4-triazine, followed by oxidative cyclization. The scope and limitations of this novel coupling reaction have been investigated. Further application of the synthesized compound has been demonstrated by synthesizing carbazole-substituted benzofuro-fused triazines. The scalability of the reaction was demonstrated at a 40 mmol load. The mechanistic study strongly suggests that this reaction proceeds through the formation of an O-coordinated manganese complex. 相似文献
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Mochulskaya Nataliya N. Nosova Emiliya V. Charushin Valery N. 《Chemistry of Heterocyclic Compounds》2021,57(4):374-382
Chemistry of Heterocyclic Compounds - The review outlines the results of studies of the antiviral activity of quinoline, quinoxaline, and quinazoline derivatives published over the past 5 years.... 相似文献
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