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1.
The first aim in the present paper is to give an integral representation for Beppo Levi functions on R
n. Our integral representation is an extension of Sobolev's integral representation given for infinitely differentiable functions with compact support. As applications, continuity and differentiability properties of Beppo Levi functions are studied.Our second aim in this paper is to study the existence of limits at infinity for Beppo Levi functions. We also consider the existence of fine-type limits at infinity with respect to Bessel capacities, which yields the radial limit result at infinity. 相似文献
2.
Bioavailability study of commercial sustained-release preparations of diclofenac sodium in gastrointestinal physiology regulated-dogs. 总被引:1,自引:0,他引:1
K Sagara Y Nagamatsu I Yamada M Kawata H Mizuta K Ogawa 《Chemical & pharmaceutical bulletin》1992,40(12):3303-3306
The gastrointestinal (GI) physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin (10 micrograms/kg x 2) and intravenous atropine sulfate (0.02 mg/kg x 1). Here, the gastric acidity, the gastric emptying time and the small intestinal transit time in the regulated-dogs were respectively around pH 2, 0.7h and 4h, approximating those in healthy humans. The superiority of the regulated-dogs over the intact dogs was confirmed in comparative bioavailability studies by using two classes of commercial preparations. Both the conventional tablet and the sustained-release capsule of diclofenac sodium exhibited simple and similar average plasma concentration-time curves of free diclofenac in the intact dogs, while the latter preparation is reported to reveal a bimodal plasma curve of the drug in healthy humans. The regulated-dogs, however, permitted a bimodal average plasma pattern of the drug for the capsules due to an approximation of the GI physiology between humans and these classes of the dogs. The combined-treatment of beagle dogs with pentagastrin and atropine sulfate seems to supply a useful animal model in predicting the absorption characteristics of the sustained-release preparations and poor water-soluble drugs. 相似文献
3.
Asymmetric monobenzoylation reactions of cyclic meso-1,3- and 1,4-diols were catalyzed by a phosphinite derivative of quinidine to afford the corresponding monobenzoylated diol with good yield and enantioselectivity. [reaction: see text] 相似文献
4.
Ikuta A Mizuta N Kitahata S Murata T Usui T Koizumi K Tanimoto T 《Chemical & pharmaceutical bulletin》2004,52(1):51-56
Six novel branched beta-cyclodextrins (betaCDs) having beta-D-galactose residues on the non-reducing terminal of the sugar side chains, namely 6(1),6(4)-di-O-(beta-D-galactosyl)-betaCD (10), 6-O-(beta-D-galactosyl)-betaCD (11), 6(1),6(4)-di-O-(beta-lactosyl)-betaCD (14), 6-O-(beta-lactosyl)-betaCD (15), 6(1),6(4)-di-O-(4'-O-beta-D-galactosyl-beta-lactosyl)-betaCD (18), and 6-O-(4'-O-beta-D-galactosyl-beta-lactosyl)-betaCD (19), were chemically synthesized using the trichloroacetimidate method. The reaction products were separated by HPLC on an amino column into dibranched and monobranched betaCDs. Their structures were confirmed by mass spectrometry (MS) and two-dimensional (2D) NMR spectroscopic analysis. To study the length of the sugar side chains attached to the CD ring, which leads to differences in the functions of the branched CDs, interactions of these compounds with peanut (Arachis hypogaea) agglutinin (PNA) were investigated using an optical biosensor and an inhibition assay based on hemagglutination. The results showed that all branched betaCDs interacted with PNA, and the binding affinity was 18>14>10 and 19>15>11 when the derivatives were compared on the basis of side chain length. 相似文献
5.
Mitsuko Asai Eiji Mizuta Motowo Izawa Konomi Haibara Toyokazu Kishi 《Tetrahedron》1979,35(9):1079-1085
In this paper we report the isolation, chemical characterization and structural elucidation of Ansamitocin, a new antitumor antibiotic obtained from Nocardia No. C-15003 (N-1). Ansamitocin P-3, P-3' and P-4 with molecular formulae C32H43ClN2O9, C32H43ClN2O9 and C33H45ClN2O9, respectively, were identified as novel antibiotics. Their UV spectra resemble that of maytansine obtained from a plant source. Analysis of the PMR spectrum and spin-decoup studies of P-3 demonstrated that its skeletal structure was the same as that of maytansine. Reductive cleavage of each antibiotic gave maytansinol (P-0). Alkali hydrolysis of P-3, P-3' and P-4 gave isobutyric, butyric and isovaleric acids, respectively. P-3, P-3' and P-4 were concluded to be the isobutyrate, butyrate and isovalerate ester of maytansinol at C-3, respectively. An antitumor plant product, maytanacine, and its semisynthetic derivative, maytansinol propionate, were also produced by the same strain. 相似文献
6.
Kazuyuki Kubo Hiroshi Nakazawa Hiroyasu Inagaki Tomoyuki Miyake Tsutomu Mizuta Katsuhiko Miyoshi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8-9):2159-2160
Treatment of [Cp*(CO) 2 M{P(NHPh)(OMe) 2 }]PF 6 (M = Fe and Ru) with NaNH 2 gives metallaiminophosphoranes, Cp*(CO) 2 M{P(NPh)(OMe) 2 }. The x-ray structures and reactivity of the complexes are reported. 相似文献
7.
Shimomura K Kadono R Ohishi K Mizuta M Saito M Chow KH Hitti B Lichti RL 《Physical review letters》2004,92(13):135505
A paramagnetic muonium (Mu) state with an extremely small hyperfine parameter was observed for the first time in single-crystalline GaN below 25 K. It has a highly anisotropic hyperfine structure with axial symmetry along the <0001> direction, suggesting that it is located either at a nitrogen-antibonding or a bond-centered site oriented parallel to the c axis. Its small ionization energy (相似文献
8.
Aida H Mori K Yamaguchi Y Mizuta S Moriyama T Yamamoto I Fujimoto T 《Organic letters》2012,14(3):812-815
A phosphinite derivative that can be easily prepared in two steps from commercially available aminoindanol was found to be an effective catalyst for enantioselective acylation of diols. For the asymmetric desymmetrization of meso-1,2-diols, the corresponding monoester was obtained in up to 95% ee from the reaction in the presence of 5 mol % catalyst. 相似文献
9.
10.