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Li Changkun Li Jinglai Cui Mengxun Fu Fenghua Zhong Bohua Zhang Zhenqing 《Chromatographia》2010,71(11):1025-1030
A sensitive and selective method for determination of (S,R)-penehyclidine in rat plasma by liquid chromatography-tandem mass spectrometry is described. The procedure employed the use of an internal standard (I.S.) and a simple protein precipitation step. The method developed was linear from 0.1 to 100 ng mL−1, with a sensitivity of 0.1 ng mL−1 as the lower limit of quantification. The intra- and inter-day assay accuracy (relative error) was within 8.27% and precision (RSD) was below 6.7%. It was successfully applied to pharmacokinetic studies of (S,R)-penehyclidine in rat plasma.
相似文献2.
Changkun Li Jinglai Li Mengxun Cui Fenghua Fu Bohua Zhong Zhenqing Zhang 《Chromatographia》2010,71(11-12):1025-1030
A sensitive and selective method for determination of (S,R)-penehyclidine in rat plasma by liquid chromatography-tandem mass spectrometry is described. The procedure employed the use of an internal standard (I.S.) and a simple protein precipitation step. The method developed was linear from 0.1 to 100 ng mL?1, with a sensitivity of 0.1 ng mL?1 as the lower limit of quantification. The intra- and inter-day assay accuracy (relative error) was within 8.27% and precision (RSD) was below 6.7%. It was successfully applied to pharmacokinetic studies of (S,R)-penehyclidine in rat plasma. 相似文献
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