排序方式: 共有13条查询结果,搜索用时 15 毫秒
1.
M. B. Muratbekov M. M. Muratbekov K. N. Ospanov 《Journal of Mathematical Sciences》2008,150(6):2521-2530
In the paper, we obtain sufficient solvability conditions of a certain boundary-value problem for a nonlinear mixed-type equation
and find upper and lower estimates for Kolmogorov widths of the solution set.
__________
Translated from Fundamentalnaya i Prikladnaya Matematika, Vol. 12, No. 5, pp. 95–107, 2005. 相似文献
2.
Let M be a von Neumann algebra equipped with a normal finite faithful normalized trace τ, and let A be a tracial subalgebra of M. Let E be a symmetric quasi-Banach space on [0, 1]. We show that A has an LE(M)-factorization if and only if A is a subdiagonal algebra. 相似文献
3.
4.
5.
Nurakhmetov N. N. Omarova R. A. Ospanov Kh. K. 《Russian Journal of Coordination Chemistry》2002,28(4):272-278
Quantum-chemical calculations with the MOPAC and HYPERCHEM programs and MNDO, AM1, and PM3 methods were used to identify the reaction center in the molecules of protonated acetamide and its analogs (alkylamides) and to determine the effect of their nature on reactivity. The results of calculations are supported by IR and UV data. The change in the reactivity of alkylamides during their reaction with inorganic acids is explained by the effect of the nature of a basic or acid partner. 相似文献
6.
7.
8.
Meirambek Ospanov Suresh P. Sulochana Jason J. Paris John M. Rimoldi Nicole Ashpole Larry Walker Samir A. Ross Abbas G. Shilabin Mohamed A. Ibrahim 《Molecules (Basel, Switzerland)》2022,27(2)
Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemotype novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs were synthesized and tested for their ability to bind to the CB1 and CB2 receptor orthosteric sites. A competitive [3H]CP-55,940 binding screen revealed five compounds that exhibited >60% displacement at 10 μM concentration. Further concentration-response analysis revealed two compounds, 4k and 4q, as potent and selective CB2 ligands with sub-micromolar activities (Ki = 146 nM and 137 nM, respectively). In order to support the potential efficacy and safety of the analogs, the oral and intravenous pharmacokinetic properties of compound 4k were sought. Compound 4k was orally bioavailable, reaching maximum brain concentrations of 602 ± 162 ng/g (p.o.) with an elimination half-life of 22.9 ± 3.73 h. Whether administered via the oral or intravenous route, the elimination half-lives ranged between 9.3 and 16.7 h in the liver and kidneys. These compounds represent novel chemotypes, which can be further optimized for improved affinity and selectivity toward the CB2 receptor. 相似文献
9.
We proved Holder-type inequalities for measurable operators associated with a semi-finite von Neumann algebra, this results generalize some known Holder inequalities for matrix. 相似文献
10.
K. N. Ospanov 《Ukrainian Mathematical Journal》1996,48(11):1768-1775
For an inhomogeneous generalized Cauchy-Riemann system with nonsmooth coefficients separated from zero, we establish conditions for the solvability and estimation of a weighted solution and its first-order derivatives. 相似文献