Total synthesis of cordiaquinone K, a new antifungal and larvicidal meroterpenoid, is reported. The absolute configuration of cordiaquinone K was confirmed by the synthesis. 相似文献
The external chiral ligand-controlled asymmetric conjugate addition reaction of lithium amides with alpha,beta-unsaturated esters provided beta-amino esters in high yields and high enantioselectivities. 相似文献
A novel bromoquinolinium reagent, i.e. 1‐(3‐aminopropyl)‐3‐bromoquinolinium bromide (APBQ), was synthesized for the analysis of carboxylic acids. A simple and practical precolumn derivatization procedure using the APBQ in RP chromatography and MS (HPLC‐MS) has been developed using bile acids and free fatty acids, as the representative carboxylic acids in biological samples. The APBQ efficiently reacted with carboxylic acids at 60°C for 60 min in the presence of N,N‐dicyclohexylcarbodiimide and pyridine as the activation reagents. Because the APBQ possesses a bromine atom in the structure, the identification of a series of carboxylic acids was easily achieved due to the characteristic bromine isotope pattern in the mass spectra. The APBQ also has a quaternary amine structure, thus the positively charged derivatives are predominate for the highly sensitive detection of carboxylic acids. The APBQ was successfully applied to the selective determination of biological carboxylic acids in human plasma. The bile acids (chenodeoxycholic acid and deoxycholic acid) and several saturated (stearic acid and palmitic acid) and unsaturated free fatty acids (oleic acid and linoleic acid) were reasonably determined by HPLC‐MS under the proposed procedure. Based on the results of analyses of human plasma and saliva, the proposed procedure using APBQ seems to be applicable for the qualitative and quantitative analyses of a series of carboxylic acids in biological samples. 相似文献
We introduce a simple spray drying method for the scaleup production of spherical organic (lignin) particles with sizes between 0.85 and 1.57 µm. We assess the surface energy of the lignin particles by inverse gas chromatography to reveal their role in composites synthesized with unsaturated polyester. Such nanocomposites are shown to be transparent to electromagnetic irradiation (millimeter wave bands). The permittivity and tanδ of the composite material reached values 3.01 and 0.01 at 28 GHz with 10% lignin content. Vinyl groups were introduced on the surface of the particles to achieve enhanced interfacial adhesion, and resulted in a reduced relative permittivity (2.75). Together with wave interactions, the mechanical and thermal properties of the composites are put in perspective, opening new opportunities in the development of bio-based devices for 5G high-speed communication.
A co-cross-linking reaction of bio-based multi-functional epoxides (1) derived from limonene oxide and bisphenol A diglycidyl ether (BPADE) in the presence of 2-ethyl-4-methylimidazole (EMI) as a cross-linker afforded the corresponding network copolymers (2) having the 10% thermal decomposition temperature (Td10) of 294.4?°C at maximum. Adhesive strength induced by 1, especially tetra-functional epoxide, and BPADE exhibited remarkably higher than that by BPADE alone. 相似文献
Root chemicals and evolutionarily neutral DNA regions in L. cyathiceps samples collected in the Zhongdian (Shangrila) County of Yunnan, P. R. China, were examined. Twenty compounds were isolated, including three new ones, 1β,10β‐epoxy‐6β‐(propionyloxy)furanoeremophilan‐9‐one ( 6 ), 1β,10β‐epoxy‐8α‐ethoxyeremophila‐6,11‐diene ( 14 ), and 11αH‐6β‐isobutyryloxy‐1β,10β,7β,8β‐diepoxyeremophilan‐12,8α‐olide ( 15 ). The chemical diversity was found to be limited, with cacalol ( 1 ) and 6‐(acyloxy)furanoeremophilan‐9‐ones ( 4 and/or 5 ) being major components in all the samples. The nuclear ribosomal RNA gene was also found to harbor little variation, although two distinct sequence types were found for the plastid atpB‐rbcL intergenic region. 相似文献
Two samples of Cremanthodium stenactinium (Asteraceae) were collected in Sichuan Province, China. From the ethyl acetate extracts of the roots, three new eremophilane-type sesquiterpenoids and one new trinoreremophilane compound were isolated, together with other known eremophilanes. Their structures were determined based on the spectroscopic data. This is the first report of isolation of eremophilane-type compounds from the genus Cremanthodium. 相似文献