Compounds for radionuclide imaging and therapy of malignant foci characterized by the increased angiogenesis

The literature data on the application and synthetic methods of compounds for imaging and therapy of malignant foci characterized by the increased angiogenesis are summarized.     

Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

Russian Journal of General Chemistry - The binding of 68Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and...     

Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

Journal of Radioanalytical and Nuclear Chemistry - Releasing radionuclide elements from nuclear activities became an important issue. Preparation of activated charcoal-Prussian blue nanoparticles...     

Synthesis and crystal structure of anilinium pertechnetate and perrhenate at low and room temperatures

Anilinium pertechnetate (I) and perrhenate (II) salts were synthesized for the first time and their crystal structure was studied. The crystals of the compounds are isostructural (monoclinic system, space group P2₁/c). On cooling from 293 to 100 K, both compounds undergo a phase transition with doubling of the parameter a, the isostructural character being retained and the space group remaining the same. The phase transitions are accompanied by strengthening and change in the H-bond system.     

Structure and solubility of tetrapropylammonium pertechnetate and perrhenate

The crystal structure was determined and the physicochemical properties were studied for tetrapropylammonium pertechnetate and perrhenate. Pr₄NMO₄ (M = Tc, Re) are isostructural and crystallize as colorless prismatic crystals in the orthorhombic system, space group Pna2₁, Z = 4. For M = Tc at 25°C, a = 13.22(4) Å, b = 12.35(3) Å, c = 10.13(4) Å; for M = Re at ?120°C, a = 13.169(2) Å, b = 12.311(2) Å, c = 10.107(1) Å. The Re-O distances are 1.677(12), 1.704(5), 1.719(4), and 1.739(11) Å. Each anion in this structure has four neighboring cations with Re…N distances of 5.06–5.34 Å. The solubility product of Pr₄NTCO₄ is (6.19 ± 0.50) × 10^?5 mol²/L². The Gibbs energy of dissolution of [(C₃H₇)₄N]TcO₄ in dilute aqueous solutions is 24.0 ± 0.5 kJ/mol. The association constant K ₁ for (Pr₄N⁺)…(TcO ₄ ^? ) in water and aqueous solutions is 10.8 ± 0.7 L/mol. The solubility of Pr₄NTcO₄ increases with the solution acidity, similarly to the solubility of Bu₄NTcO₄. Upon precipitation of Pr₄NTcO₄ from model solutions containing (2.0–7.5) × 10^?2 mol/L Tc in 3–4 M HNO₃, (2.0–7.5) × 10^?8 mol/L ²³⁹PuO₂(NO₃)₂, and 5.7 mCi/L ¹⁰⁶Ru(NO)(NO₃)₃, the technetium decontamination factors from ²³⁹Pu and ¹⁰⁶Ru were (0.5–1.5) × 10² and (6.0–7.5) × 10², respectively.     

Lithium pertechnetate trihydrate LiTcO<Subscript>4</Subscript> · 3H<Subscript>2</Subscript>O: Synthesis and crystal structure

Lithium pertechnetate trihydrate was obtained and its crystal structure was examined; LiTcO₄ · 3H₂O crystallizes in hexagonal crystal system as colorless elongated prismatic crystals (space group P6₃/mc, Z = 2; at 100 K: a = 7.8604(1) Å, c = 5.4164(1) Å). This compound is isostructural with LiClO₄ · 3H₂O, LiBrO₄ · 3H₂O, and LiMnO₄ · 3H₂O.     

Synthesis, crystal structure, and properties of triphenylguanidinium perrhenate hemihydrate

Triphenylguanidinium perrhenate hemihydrate, [(C₆H₅NH)₃C]ReO₄ · 0.5H₂O (I), is synthesized, and its crystal structure and some properties are studied. The colorless extended plate-like crystals of compound I are triclinic (space group $P\bar 1$ , Z = 4, 293 K, a = 9.8716(17), b = 14.093(2), c = 15.439(3)Å, α = 99.632(9)^○, β = 101.802(9)^○, γ = 95.361(10)^○). Compound I has no isostructural analogs, and the conformations of both crystallographically independent triphenylguanidinium cations differ by a higher symmetry (C _3h ) from those for cations of this type in all other structurally studied compounds. The following parameters are determined: the upper limit of the temperature stability of compound I (383 K), the melting point of anhydrous [(C₆H₅NH)₃C]ReO₄ (Ia) of 441 K, the enthalpy of dehydration of compound I (ΔH _dehydr ^{(383 K)} = 10.0(8) kJ/mol), and the enthalpy of melting of anhydrous Ia (ΔH _m ^{(441 K)} = 16.6(9) kJ/mol).