Kakao

Ohne Zusammenfassung     

Analysis of Unsteady Motion with Respect to Noise Sources in a Gas Turbine Combustor: Isothermal Flow Case

In order to evaluate the direct and indirect contributions to the total combustion noise emission, a combustion chamber consisting of a swirl burner and an exit nozzle of Laval-shape, representing a gas turbine combustor, is investigated by means of experiments and large eddy simulation. Focused on the isothermal flow case first and encouraged by a good overall agreement between the LES and the experimental data for the flow field, a first characterisation of the flow with respect to noise sources is performed. To analyse acoustic properties of the flow, time and length scales are evaluated inside the combustor. Furthermore, the evidence for the existence of a precessing vortex core (PVC), typical for configurations with swirl, is revealed. Finally, the effect of the PVC on the flow inside the Laval nozzle is discussed.     

Factors influencing level of hydrogen peroxide in exhaled breath condensate

Hydrogen peroxide (H₂O₂) in exhaled breath condensate (EBC) has been proposed as a marker for oxidative stress in the airways. The aim of the present study was to evaluate the measurement of H₂O₂ in EBC with or without use of a nose clip, and the influence of mouth rinsing, sampling time and storage.An elevated H₂O₂ level was seen during nasal breathing compared to mouth breathing with nose clip (3.4 pmol/s vs. 2.1 pmol/s, p = 0.02). Breathing through the mouth, using a nose clip, was therefore practiced in all experiments. The H₂O₂ levels were increased when mouth rinsing was performed using an acid buffer (1.4 pmol/s vs. 1.9 pmol/s, p = 0.03). 15 min sampling time decreased the H₂O₂ output by almost 50% compared with 2 min sampling time (1.2 vs. 0.6 pmol/s, p = 0.03). When samples were left unattended for 15 min no change in H₂O₂ concentration in the EBC was seen.We found no significant differences in H₂O₂ levels between samples stored for 4 weeks at − 80 °C and samples analysed directly; however, a significant decrease in the levels was seen for samples stored for 4 weeks at − 20 °C.In conclusion, the method of EBC collection and storage plays an important role in reducing variability within and between individuals.     

Dynamic combinatorial libraries of disulfide cages in water

[structure: see text] Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.     

Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were isolated from the stem bark of Voacangaafricana. The structures of the compounds were determined by comprehensive spectroscopic analyses. Compounds 1, 2, 3, 4, 6, 7 and 8 were found to inhibit the motility of both the microfilariae (Mf) and adult male worms of Onchocerca ochengi, in a dose-dependent manner, but were only moderately active on the adult female worms upon biochemical assessment at 30 μM drug concentrations. The IC₅₀ values of the isolates are 2.49–5.49 µM for microfilariae and 3.45–17.87 µM for adult males. Homology modeling was used to generate a 3D model of the O. ochengi thioredoxin reductase target and docking simulation, followed by molecular dynamics and binding free energy calculations attempted to offer an explanation of the anti-onchocercal structure–activity relationship (SAR) of the isolated compounds. These alkaloids are new potential leads for the development of antifilarial drugs. The results of this study validate the traditional use of V. africana in the treatment of human onchocerciasis.     

Zur Berechnung des Extraktgehaltes nach Windisch bei Gegenwart unl?slicher Stoffe

Ohne Zusammenfassung     

Optical measurement of acoustic pressure amplitudes-at the sensitivity limits of Rayleigh scattering

Rayleigh scattering is a measurement technique applicable for the determination of density distributions in various technical or natural flows. The current sensitivity limits of the Rayleigh scattering technique were investigated experimentally. It is shown that it is possible to measure density oscillations caused by acoustic pressure oscillations noninvasively and directly. Acoustical standing waves in a rectangular duct were investigated using Rayleigh scattering and compared to microphone measurements. The comparison showed a sensitivity of the Rayleigh scattering technique of 75 Pa (7·10(-4) kg/m(3)) and a precision of 14 Pa (1·10(-4) kg/m(3)). Therefore, it was also shown that Rayleigh scattering is applicable for acoustic measurements.     

Photon and positron generation by ultrahigh intensity laser interaction with electron beams

This study investigates the generation of high energy photons and positrons using focused ultrahigh intensity femtosecond laser pulses on a relativistic electron beam with a set of two-dimensional particle-in-cell simulations. We consider circularly and linearly polarized, single and spatially separated double laser pulses. We model both 500 MeV and 1 GeV electron beams. Higher positron production is obtained using circularly polarized laser pulses. Using double pulses, the focusing effect of the ponderomotive force confines the electrons to a small volume, generating additional energetic photons and positrons. The positron spectral distributions are effectively modified by these variations. When the electron beam energy is doubled, the number of positrons increased, while the cutoff energy remained nearly constant.     

Coupled-channels effects for inelastic scattering of 15 MeV polarized deuterons from Ti and Sm isotopes

Cross sections and analyzing powers have been measured for elastic and inelastic scattering of 15 MeV deuterons from ¹⁴⁸'Sm and ¹⁵²Sm. These data, as well as previous data for the ${}^{\mathrm{48,\; 50}}\text{Ti}\text{(}\text{d}\text{, d'}\text{)}$ reaction have been analyzed in the coupled-channels approximation. Data for ⁴⁸Ti and ¹⁵²Sm are better described by the rotational model than by the vibrational model but the quality of the fits is not sufficiently good to establish ($\text{d}\text{, d'}$) reactions as a sensitive method of discriminating between these two models.     

Electron-positron pair production in a strong asymmetric laser electric field

By solving the quantum Vlasov equation, electron positron pair production in a strong electric field with asymmetric laser pulses has been investigated. We consider three different situations of subcycle, cycle and supercycle laser pulses. It is found that in asymmetric laser pulse field, i.e.. when the pulse length of one rising or falling side is fixed while the pulse length of the other side is changed, the pair production rate and mnnber density can be significantly modified comparable to symmetric situation. For each ca,se of these three different cycle pulses, when one side pulse length is constant and the other side pulse length becomes shorter, i.e., the whole pulse is compressed, the more pairs can be produced than that in tile vice versa case, i.e., the whole pulse is elongated. In compressed pulse case there exists an optimum pulse length ratio of asylnmetric pulse lengths which makes the pair number density maximunn. Moreover, the created maximum pair number density by subcycle pulse is larger than that by cycle or/and supercycle pulse. In elongated pulse case, however, only for supercycle laser pulse the created pairs is enhanced and there exists also an optimum asymmetric pulse length ratio that maximizes the pair number density. On the other hand. surprisingly, in both cases of subcycle and cycle elongated laser pulses, the pair number density is monotonically decreasing as the asymmetry of pulse increases.