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Dr. Srivari Chandrasekhar Kakita Veera Mohana Rao Mallikanti Seenaiah Police Naresh Ambure Sharada Devi Dr. Bharatam Jagadeesh 《化学:亚洲杂志》2014,9(2):457-461
Hybrid peptidic oligomers comprising natural and unnatural amino acid residues that can exhibit biomolecular folding and hydrogen‐bonding mimicry have attracted considerable interest in recent years. While a variety of hybrid peptidic helices have been reported in the literature, other secondary structural patterns such as γ‐turns and ribbons have not been well explored so far. The present work reports the design of novel periodic γ‐turns in the oligomers of 1:1 natural‐α/unnatural trans‐β‐norborenene (TNAA) amino acid residues. Through DFT, NMR, and MD studies, it is convincingly shown that, in the mixed conformational pool, the heterogeneous backbone of the hybrid peptides preferentially adopt periodic 8‐membered (pseudo γ‐turn)/7‐membered (inverse γ‐turn) hydrogen bonds in both polar and non‐polar solvent media. It is observed that the stereochemistry and local conformational preference of the β‐amino acid building blocks have a profound influence on accessing the specific secondary fold. These findings may be of significant relevance for the development of molecular scaffolds that facilitate desired positioning of functional side‐chains. 相似文献
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Synthesis and Antimicrobial Activity of Amido Sulfonamido Methane Linked Bisoxazoles,Bisthiazoles, and Bisimidazoles
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Chokkappagari Premakumari Dandu Seenaiah Akula Srilakshmi Divi Venkata Ramana Sai Gopal Venkatapuram Padmavathi 《Journal of heterocyclic chemistry》2014,51(6):1875-1882
A new class of amido sulfonamido methane linked bisoxazoles, bisthiazoles, and bisimidazoles were prepared adopting simple and versatile synthetic methodologies. The lead compounds were assayed for antimicrobial activity. 相似文献
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A facile synthesis of 1-alkyl benzotriazoles is achieved through fluoride triggered azide-benzyne cycloaddition. Various alkyl azides were treated with 2-(trimethylsilyl) phenyl triflate in the presence of CsF in acetonitrile to afford the corresponding substituted benzotriazoles in good yield. 相似文献
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Novel sulfur-containing spiro compounds such as 7,11-diaryl-9-thia-2,4-diazaspiro [5,5] undecane-1,3,5-trione 9,9-dioxides ( 2 ), 6,10-diaryl-8-thia-2,3-diazas-piro[4,5]decane-1,4-dione-8,8-dioxides ( 3 ) and 6,10-diaryl-2-oxo-8-thia-3-azaspiro [4,5] decane-1,4-dione-8,8-dioxides ( 5 ) have been prepared by the condensation of 4-dimethoxycarbonyl/diethoxycarbonyl-3,5-diaryl-1-thiane 1,1-dioxides ( 1 ) with urea, hydrazine hydrate, and hydroxylamine hydrochloride, respectively. The N-substituted derivatives ( 4 and 6 ) of 3 and 5 have also been prepared by acylation and nitrosation. The structures of 2, 3 , and 5 were established by IR, 1H NMR, and 13C NMR spectral studies, respectively. 相似文献
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Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles
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Padmavathi Venkatapuram Seenaiah Dandu Premakumari Chokkappagari Padmaja Adivireddy 《Journal of heterocyclic chemistry》2014,51(6):1757-1763
A new class of sulfonylmethane linked bisheterocycles were prepared and studied their antimicrobial activity. 相似文献
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Padmavathi Venkatapuram Sreelatha Tumma Seenaiah Dandu Premakumari Chokkappagari 《Journal of heterocyclic chemistry》2015,52(3):756-763
The amido‐linked oxazolyl/thiazolyl/imidazolyl pyrazoles and isoxazoles were prepared from the synthetic intermediates oxazolyl/thiazolyl/imidazolyl acrylamides adpoting1,3‐dipolar cycloaddition of nitrile imines and nitrile oxides. 相似文献
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Srivari Chandrasekhar Mallikanti SeenaiahAbhishek Kumar Chada Raji ReddySuman Kumar Mamidyala Chityal Ganesh KumarSridhar Balasubramanian 《Tetrahedron letters》2011,52(7):806-808
Synthesis of a series of [1,2,3] triazolo [5,1-c] [1,4]benzoxazepine derivatives have been accomplished by the intramolecular Cu(I)-catalyzed cycloaddition of azido-alkynes derived from salicylaldehyde. The biological profile of these heterocyclic structural scaffolds toward anti-bacterial as well as anti-fungal activity has also been illustrated. 相似文献
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