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Published data describing the current status and prospects for the development of clinical diagnostics of a number of neurodegenerative and neuroendocrine diseases associated with neurotransmitter balance disorders in a human body are generalized, systematized, and assessed in the review. Characteristics, advantages, and limitations of neuroimaging techniques and different diagnostic methods based on measuring concentrations of protein markers, catecholamines, and their metabolites are discussed. Prospects of the application of optical methods, such as fluorimetry and surface-enhanced Raman spectroscopy, to the development of sensor systems for the diagnosis of these diseases by the concentration of catecholamines and their metabolites in biological fluids are demonstrated.  相似文献   
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The results of hydrochemical and hydrobiological studies performed in October 2009, July 2010, and July 2016 in the Blagopoluchiya Bay of Solovetsky Island are given. The concentrations of petroleum hydrocarbons, phenols, oxygen, nutrients, and chlorophyll a, BOD5, and qualitative and quantitative compositions of phytoplankton have been determined. The integrated pollution and eutrophication indices have been calculated, and the up-to-date water quality in the Blagopoluchiya Bay has been assessed; increased level of seawater pollution has been revealed. The obtained results are important from both scientific and practical viewpoints with respect to environmental safety of the community facilities in the study region.

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