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Prathama S. Mainkar Chirumarry Sridhar Ambadi Sudhakar Srivari Chandrasekhar 《Helvetica chimica acta》2013,96(1):99-108
The synthesis of bolaamphiphiles from unusual β‐amino acids or an alcohol and C12 or C20 spacers is described. Unusual β‐amino acids such as a sugar amino acid, an AZT‐derived amino acid, a norbornene amino acid, and an AZT‐derived amino alcohol were coupled with spacers under standard conditions to get the novel bolaamphiphiles 5 – 8 (Scheme 1), 12 and 13 (Scheme 2), and 17 and 20 (Scheme 3). Some of these compounds, on precipitation from MeOH/H2O, self‐assembled into organized molecular structures. 相似文献
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S. G. Dani Meera G. Mainkar 《Transactions of the American Mathematical Society》2005,357(6):2235-2251
We associate with each graph a -step simply connected nilpotent Lie group and a lattice in . We determine the group of Lie automorphisms of and apply the result to describe a necessary and sufficient condition, in terms of the graph, for the compact nilmanifold to admit an Anosov automorphism. Using the criterion we obtain new examples of compact nilmanifolds admitting Anosov automorphisms, and conclude that for every there exist a -dimensional -step simply connected nilpotent Lie group which is indecomposable (not a direct product of lower dimensional nilpotent Lie groups), and a lattice in such that admits an Anosov automorphism; we give also a lower bound on the number of mutually nonisomorphic Lie groups of a given dimension, satisfying the condition. Necessary and sufficient conditions are also described for a compact nilmanifold as above to admit ergodic automorphisms.
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S. Chandrasekhar Mrunal Pendke Chandrashekar Muththe Srirama Murthy Akondi Prathama S. Mainkar 《Tetrahedron letters》2012,53(10):1292-1295
A straight forward entry to α,α-dideutero-β-amino esters starting from the corresponding imines and deuterated acetonitrile has been developed involving a two-step process. 相似文献
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Abstract A synthetic strategy wherein C-l/6 of D-glucose are transformed into C-6/1 of L-daunosamine, circumventing the critical step of epimerisation of the C-5 center is described. 相似文献
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Kingshuk Panda Kalichamy Alagarasu Poonam Patil Megha Agrawal Ashwini More Naveen V. Kumar Prathama S. Mainkar Deepti Parashar Sarah Cherian 《Molecules (Basel, Switzerland)》2021,26(10)
Dengue virus (DENV), a member of the family Flaviviridae, is a threat for global health as it infects more than 100 million people yearly. Approved antiviral therapies or vaccines for the treatment or prevention of DENV infections are not available. In the present study, natural compounds were screened for their antiviral activity against DENV by in vitro cell line-based assay. α-Mangostin, a xanthanoid, was observed to exert antiviral activity against DENV-2 under pre-, co- and post-treatment testing conditions. The antiviral activity was determined by foci forming unit (FFU) assay, quantitative RT-PCR and cell-based immunofluorescence assay (IFA). A complete inhibition of DENV-2 was observed at 8 µM under the co-treatment condition. The possible inhibitory mechanism of α-Mangostin was also determined by docking studies. The molecular docking experiments indicate that α-Mangostin can interact with multiple DENV protein targets such as the NS5 methyltransferase, NS2B-NS3 protease and the glycoprotein E. The in vitro and in silico findings suggest that α-Mangostin possesses the ability to suppress DENV-2 production at different stages of its replication cycle and might act as a prophylactic/therapeutic agent against DENV-2. 相似文献
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Meera G. Mainkar 《Monatshefte für Mathematik》2012,165(1):79-90
We study nilmanifolds admitting Anosov automorphisms by applying elementary properties of algebraic units in number fields to the associated Anosov Lie algebras. We identify obstructions to the existence of Anosov Lie algebras. The case of 13-dimensional Anosov Lie algebras is worked out as an illustration of the technique. Also, we recapture the following known results: (1) Every 7-dimensional Anosov nilmanifold is toral, and (2) every 8-dimensional Anosov Lie algebra with 3 or 5-dimensional derived algebra contains an abelian factor. 相似文献
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Kurapati Sathish Gangireddy Pavan Kumar Reddy Prathama S. Mainkar Srivari Chandrasekhar 《Tetrahedron: Asymmetry》2011,22(14-15):1568-1573
The synthesis of the ‘southern’ tripeptide of Cyclomarins A and C has been described which includes two unusual amino acids. The unusual amino acids have been synthesized and coupled with l-alanine to obtain the tripeptide. 相似文献
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Loline alkaloids exhibit a strained ether-bridged pyrrolizidine skeleton and possess insecticidal and insect antifeedant properties. The synthesis of acetylnorloline, a prototypical member of the alkaloid family, is described. Central to the route is a stereoselective tethered aminohydroxylation (TA) of a homoallylic carbamate. Allylic (A1,3) strain is exploited to enforce diastereofacial selectivity during the aminohydroxylation. 相似文献