Derivatives of n-(pyrimid-4-yl)ethylamine

In order to find compounds possessing antibacterial activity, a number of new derivatives of N-(pyrimid-4-yl)ethylamine have been synthesized from 5-amino-4, 6-dichloropyrimidine, 2-amino-4, 6-dichloro-pyrimidine, 4, 6-dichloro-2-phenylpyrimidine, and 2,4-dichloro-6-methylpyrimidine and various ethylamines substituted in the -position. Several derivatives of 4-(4-methylpiperazinyl)pyrimidine have also been obtained. Results of a biological study of the compounds obtained are presented.For part II, see ¦1¦.     

5-Substituted pyrimidine derivatives

The properties and reactivities of 4-hydroxy- and 2,4-dihydroxy-5-(β-hydroxyethyl)pyrimidines and of the products of their transformations have been studied. 4-Chloro- and 2,4-dichloro-5-(β-chloroethyl)pyrimidines have been obtained. A number of 4-alkyl(aryl)amino-5-(β-chloroethyl)pyrimidines have been synthesized, and they have been converted into derivatives of 5,6-dihydropyrrolo[2,3-d]pyrimidine.     

5-Aminoorotic acid derivatives

The 2,4,8-trioxo derivative of pyrimido[5,4-d][1,3]oxazine was synthesized, and esters and amides of 5-acetamidoorotic acid were obtained from it. The acetyl group in 5-acetamido-orotic acid esters is readily hydrolyzed in acidic media to give esters of 5-aminoorotic acid, while the acetyl group in amides of 5-acetamidoorotic acid do not undergo hydrolysis.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 270–272, February, 1973.Deceased.     

Effect of transport in a semiconductor thermoelectric generator on its efficiency

The effects of electrical transport and thermal diffusion in the working medium of a thermoelectric generator (TEG) on its efficiency and maximum useful power are examined. Equations are derived to describe these effects, and dimensionless parameters are found whose values are governed by the thermodynamic and kinetic characteristics of the material. Numerical estimates carried out show that it is possible to increase the efficiency and power of a TEG by selecting materials having suitable transport characteristics. The semiconductor alloys of the T1-S system are interesting in this regard.Translated from Izvestiya Vysshikh Uchebnykh Zavedenii Fizika, No. 8, pp. 63–69, August, 1969.     

Study of lactams. VII. Synthesis and some reactions of lactim ethers of 3,3-diethyl-5-methylpiperidine-2,4-dione and 3-carbethoxypiperid-2-one

Chemistry of Heterocyclic Compounds -     

Some substituted 4-aminothionaphtheno [3, 2-d] pyrimidines

Boiling 2-methyl-4-oxo-3,4-dihydrothionaphtheno[3,2-d]-pyrimidine with phosphorus oxychloride gives 2-methyl-4-chlorothionaphtheno [3,2-d]pyrimidine (II), in which the chlorine atom is mobile. Nucleophilic substitution of the mobile chlorine atom in compound II gives the 4-ethoxy,4-(N-piperidino),4-(N⁴-methyl-N-piperazino), 4-[2-(diethylamino)ethylamino],4-3-(diethylamino)-2-hydroxypropylamino]substituted derivatives.     

Study of lactams. VI. Synthesis of 6-substituted purino [8, 9-11, 22]isoindol1nes

It is shown with 1-ethoxyisoindolenine that the reaction of lactim ethers with -amino--cyanoacetamide also extends to partly aromatized lactim ethers, although these react much less readily. Condensation of 1-ethoxyisoindolenine with -amino-cyanoacetamide gives 4-carbamido-5-aminoimidazo[1, 2-1, 2]isoindoline, from which a new series of purinoisoindioline derivatives is synthesized.For part V see [2].     

N-(4-Pyrimidyl)ethylamine derivatives

In order to find antitumoral agents, a number of new N-(4-pyrimidyl) ethylamine derivatives have been synthesized from 4,6-dichloropyrimidine, 6-amino-4-chloropyrimidine, 4-chloro-6-hydroxypyrimidine, and various ethylamines substituted in the position.     

Synthesis of 5-Phenylamino derivatives of orotic acid

The possibility of nucleophilic substitution of bromine in 5-bromoorotic acid by aromatic amines was studied. 5-Phenylamino derivatives of uracil and 5-phenylamino derivatives of orotic acid were synthesized.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 273–275, February, 1973.Deceased.