One-pot Three-component Synthesis of 3,4-Dihydroquinazolin- 4-one Derivatives under Aqueous Medium or Solvent-free Conditions

3,4-Dihydroquinazolin-4-one derivatives were synthesized in moderate to high yields by one-pot condensation of anthranilic acid, amines, and formic acid or orthoester without catalyst under aqueous medium or solvent-free conditions.     

Synthesis of 1,4-Benzothiazine Compounds Containing Isatin Hydrazone Moiety as Antimicrobial Agent

A series of novel 3‐methyl‐N"‐(2‐oxoindolin‐3‐ylidene)‐4H‐benzo[b][1,4]thiazine‐2‐carbohyrazides have been synthesized and studied on their in vitro antimicrobial activity potency to establish structure‐activity relationship. Several compounds demonstrated promising antifungal and antibacterial activity; however, other tested compounds exhibited moderate to poor antimicrobial activity with respect to the reference drug against the test strains.