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1.
Synthesis of β-D -Glucopyranosides of some Hydroxylated Vitamin-D Compounds Cholesta-5, 7-diene-1α, 3β-diol (1a) was glycosylated with ‘α-acetobromoglucose’ (2) as well as with ‘α-acetobromocellobiose’ (4) to yield the 3-(glycosides) 1b and 1c , respectively. Irradiation of these products with UV light followed by thermal isomerization led to the corresponding vitamin-D derivatives 3a and 3c. Direct glucosylation of vitamin D3 (3f) and vitamin D2 (5a) with 2 gave the derivatives 3g and 5b , respectively. With 25-hydroxycholecalciferol ( = calcidiol; 6a ) as substrate, besides the 3-(glucoside) 6b small amounts of the C(25)-analog 6c were formed. The reaction of 1α, 25-dihydroxycholecalciferol ( = calcitriol; 6e ) with 2 furnished the 3- and the 1-(glucoside) ( 6f and 6g , respectively) as the major components and the C(25)-analog 6h in minor quantity. From the acetylated 3-(glucosides) 3a, 3g, 5b, 6b , and 6f , the free glucopyranosides 3b, 3h, 5c, 6d , and 6i , respectively, were prepared as well as the free glucopy-ranosyl-glucopyranoside 3d from the acetylated disaccharide 3c. 相似文献
2.
Stanoeva T Neshchadin D Gescheidt G Ludvik J Lajoie B Batchelor SN 《The journal of physical chemistry. A》2005,109(49):11103-11109
The degradation of dyes is frequently initiated by one-electron oxidation or reduction; however, relatively little is known about the initially formed radicals. Acid Green 25 (AG25), Crystal Violet (CVI), Methylene Blue (MB), and Acid Orange 7 (AO7), representing paradigms of four types of commercial organic dyes, were therefore investigated in terms of their redox behavior. Their redox potentials in MeCN and buffered aqueous solutions were determined by cyclic voltammetry. The structures of the one-electron reduced and oxidized dyes were established by EPR spectroscopy and by theoretical calculations on the density functional level of theory. 相似文献
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Jan Tauchen Lukas Huml Ludvik Bortl Ivo Doskocil Veronika Jarosova Petr Marsik 《Natural product research》2019,33(18):2718-2721
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use. 相似文献
5.
A CW CO2 laser ablation technique is used to form buried waveguides in planar silica films. It is shown that the refractive index of a silica thin film is reduced sufficiently adjacent to the laser processed region to allow the fabrication of low loss waveguides. The refractive index distribution of these structures is measured using the reflectance of a focussed spot from the surface of the films. The change in refractive index is measured to be of the order of the core cladding refractive index difference of typical single mode waveguides. The spatial resolution of the reflectance technique is 1.3 μm with a refractive index resolution of ±5 × 10?4. Devices such as 1 × 2 and 1 × 4 multi-mode interference (MMI) splitters have also been demonstrated and shown to exhibit low transmission losses. 相似文献
6.
The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units ( 3 – 7 ). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-O-trityl derivative 18 . The resulting acid 16 was esterified to 17 in large mounts using methyl chloroformate/base. Trimethylsilyl bromide proved to be an excellent reagent for the hydrolysis of a prop-1-enyl glycoside ( 19 →21 ). The pentasaccharide 29 was obtained by a [2 + 2] + 1 synthesis, the glycosylation reactions furnished good to very good yields. The identity of protected oligosaccharides was confirmed by 1H-NMR spectroscopy. Sequential deblocking of the pentasaccharide, O-sulfation, and N-acetylation gave 2 which was shown to exhibit ca. 600 times lower anticoagulant activity than pentasaccharide 1 . 相似文献
7.
Ludvik Janos 《Annali di Matematica Pura ed Applicata》1977,112(1):273-283
Summary We consider the boundary value problem αz″(x)+m(x)y(x)=0, αy″(x)+p(x)z(x)=0, xε[0, 1], y(0)=y(1)=z(0)=0, where the functions m(x) and p(x) are assumed integrable and positive everywhere in [0, 1]. As the main result we obtain the inequalities
for n=1, 2, ... where δn(m, p) stands for the product
of the first n eigenvalues αi(m, p) of the above system and where δn(m) abbreviates δn(m, m).
Entrata in Redazione il 6 febbraio 1976. 相似文献
8.
Jürg Gutzwiller Ludvik Labler Werner Meier Andor Fürst Ulrich Eder Gerhard Sauer Rudolf Wiechert 《Helvetica chimica acta》1978,61(7):2397-2406
Total Synthesis of (+)-D-Homo-19-nortestosterone A novel total synthesis of (+)-D-homo-19-nortestosterone ( 2 ) is described starting from (4a S, 5S)-5-(t-butoxy)-4a-methyl-4, 4a, 5, 6, 7, 7-hexahydro-3 H-naphthalen-2-one ( 3 ) as a chiral building block for the rings C and D. The key step involves combining of the derived reactive one-carbon atom adducts 5 and 6 with the β-keto ester 16 , a synthon for the rings A and B, to give the Δ9-4, 5-secosteroid 21 . 21 was readily transformed to the title compound 2 by hydrogenation and subsequent ring closure. Hydrogenation of the derived 3, 5-dione 22 followed by base-catalyzed cyclization gave the 17a-t-butoxy compound 27 and the 9β, 10α-D-homosteroid 29 as by-product. 相似文献
9.
Andor Fürst Ludvik Labler Werner Meier Karl-Heinz Pfoertner 《Helvetica chimica acta》1973,56(5):1708-1710
1α-hydroxycholesterol ( 4a ) was synthesized from cholesterol and transformed via its diacetyl derivative 4b into 1α, 3β-diacetoxycholesta-5, 7-diene ( 6b ). Irradiation of the ring-B-diene 6b followed by thermal isomerization and saponification gave 1α-hydroxycholecalciferol ( 7 ). 相似文献
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