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Synthesis of 1-Aroyl-4-(2-Chlorophenyloxyacetyl)-Thiosemicarbazides and Corresponding Semicarbazides
1,4-Diacyl thiosemicarbazides have attracted much attention in recent years because of their fungicidal1, bactericidal2 and tuberculostatic3 activities. Meanwhile, aryloxyacetic acid derivatives have also been used as herbicides and plant-growth regulators4-6. These applications prompt us to synthesize a new series of compounds bearing both thiosemicarbazide and aryloxyacetyl moiety, with the objective of further investigating the property and structure-activity relationship of these new compounds and obtaining new biologically active compounds. In addition, the species of 1,4-diacyl semicarbazides are still very scarce, so an efficient synthetic route from 1,4-diacyl thiosemicarbazides to 1,4-diacyl semicarbazides is also introduced in this paper. 相似文献
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