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1.
V. I. Potkin N. A. Bumagin A. V. Kletskov S. K. Petkevich P. V. Kurman 《Russian Journal of Organic Chemistry》2016,52(11):1661-1669
From (4,5-dichloroisothiazol-3-yl)phenylmethanol by Ritter reaction a substituted acetamide was synthesized that at hydrolysis with HCl afforded (4,5-dichloroisothiazol-3-yl)phenylmethylamine hydrochloride. By reaction of (5-arylisoxazol-3-yl)- and 4,5-dichloroisothiazol-3-yl)arylmethanol with thionyl chloride the corresponding (1,2-azol-3-yl)arylchloromethanes were obtained. At treatment with O- and N-nucleophiles chlorine atom in chloromethylеne fragment of obtained compounds was substituted by residues of benzylamine, morpholine, vanillin, and ethoxy group. 相似文献
2.
V. I. Potkin Yu. S. Zubenko N. I. Nechai A. I. Bykhovets P. V. Kurman 《Russian Journal of Organic Chemistry》2008,44(7):1038-1042
By treating with phosphorus pentoxide the 4,5-dichloroisothiazole-3-carboxamide 4,5-dichloro-3-cyanoisothiazole was synthesized whose reactions with piperidine, phenyl-and benzylthiols occurred with replacement of the chlorine atom in the position 5 by the residue of the corresponding nucleophile. Reactions with sodium thiobytylate and also with sodium methylate in methanol led to the formation both of the products of chlorine substitution by BuS or MeO groups respectively and of addition products of methanol to the cyano group. The reaction of butanethiol with cyanoisothiazole in 2-propanol in the presence of sodium 2-propylate was more selective and resulted in the replacement of the chlorine atom in the position 5 by the residue of the butanethiol. 相似文献
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4.
S. K. Petkevich E. A. Dikusar A. V. Kletskov I. B. Rozenzveig G. G. Levkovskaya P. V. Kurman R. M. Zolotar’ V. I. Potkin 《Russian Journal of General Chemistry》2018,88(2):234-240
Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides. 相似文献
5.
Kolesnyk I. A. Petkevich S. K. Tsaryk A. D. Kurman P. V. Potkin V. I. 《Russian Journal of Organic Chemistry》2020,56(1):20-28
Russian Journal of Organic Chemistry - The reaction of 3,4,4-trichloro-1,1-bis(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-diene with 2-aminopyridine gave a polysubstituted... 相似文献
6.
Dikusar E. A. Petkevich S. K. Zhukovskaya N. A. Zvereva T. D. Kurman P. V. 《Russian Journal of Organic Chemistry》2019,55(4):462-468
Russian Journal of Organic Chemistry - Convenient synthetic approaches to functionally substituted 5-phenyl-1,2-oxazole-3-carboxamides and 4,5-dichloro-1,2-thiazole-3-carboxamides were developed on... 相似文献
7.
O. V. Gulyakevich P. V. Kurman A. S. Lyakhov A. L. Mikhal’chuk 《Chemistry of Heterocyclic Compounds》2006,42(1):70-76
Treatment of 3,4-dihydroisoquinolines with triacetylmethane in refluxing alcohol for 2-3 h gave 3-acetyl-4-methylpyrido[2,1-a]isoquinolin-2-ones.
Their basic physicochemical properties have been studied.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 77–85, January, 2006. 相似文献
8.
V. I. Potkin V. L. Shirokii S. K. Petkevich P. V. Kurman 《Russian Journal of General Chemistry》2008,78(8):1573-1576
Friedel-Crafts acylation of ferrocene and cymantrene with 3,4,4-trichlorobut-3-enoyl chloride gave the corresponding trichloroallyl ferrocenyl and cymantrenyl ketones. The reaction with ferrocene involved either one or both cyclopentadienyl fragments, depending on the reactant ratio. The acylation of acetylferrocene with 3,4,4-trichlorobut-3-enoyl chloride afforded 1-acetyl-1′-(3,4,4-trichlorobut-3-enoyl)ferrocene. 相似文献
9.
The reaction of 3,4,4-trichloro-1-(2-thienyl)but-3-en-1-one with hydroxylamine gave 3-hydroxyiminomethyl-5-(2-thienyl)isoxazole
which was converted into 5-(2-thienyl)isoxazole-3-carbonitrile by the action of acetic anhydride in pyridine. 5-(2-Thienyl)isoxazole-3-carbonitrile
reacted with hydroxylamine to produce the corresponding amide oxime. Heterocyclization of its O-acyl derivatives in acetic acid afforded 5-substituted 3-[5-(2-thienyl)isoxazol-3-yl]-1,2,4-oxadiazoles. 相似文献
10.
V. I. Potkin S. K. Petkevich P. V. Kurman 《Russian Journal of Organic Chemistry》2007,43(11):1622-1627
Reactions of 2-bromo-1-phenyl- and 2-bromo-1-(4-methylphenyl)-3,4,4-trichlorobut-3-en-1-ones with morpholine and diethylamine are accompanied by prototropic allylic rearrangement, leading to 3-amino-1-aryl-2-bromo-4,4-dichlorobut-2-en-1-ones as mixtures of E and Z isomers. The title compounds react with hydrazine, hydroxylamine, and thiourea to give the corresponding 5-aroyl-4-methoxypyrazoles, 3-aryl-5-hydroxyiminomethyl-4-methoxyisoxazoles, and 2-amino-4-aryl-5-trichlorovinylthiazoles. 相似文献