Synthesis and antifungal activity of 3-substituted imidazo[1,2-<Emphasis Type="Italic">b</Emphasis>][1,2,4,5]tetrazines

A number of new 3-substituted imidazo[1,2-b][1,2,4,5]tetrazines containing azolyl, aminopyridyl, and alkoxyl substituents was synthesized. These compounds were studied for the biological activity against mycelial anthropophilic and zoophilous dermatophyte fungi (Trichophyton, Microsporum and Epidermophyton), causing diseases of skin and its appendages (hair, nails), and yeast-like fungi Candida.     

Synthesis and tuberculostatic activity of new 3-alkylthio-6-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines

Russian Chemical Bulletin - A number of new 3-alkylthio-6-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]-tetrazines were synthesized and modified in nucleophilic substitution reactions...     

Synthesis and reactions of 7-phenylimidazo[1,2-b][1,2,4,5]tetrazines with nucleophiles

Russian Chemical Bulletin - A series of novel 3-substituted 7-phenylimidazo[1,2-b][1,2,4,5]tetrazines was synthesized via the reaction of 3-R-amino-1,2,4,5-tetrazines with 2-aminoacetophenone. The...     

Reactions of 1,2,4,5-tetrazines with S-nucleophiles

The reactions of 3,6-disubstituted and azoloannulated 1,2,4,5-tetrazines containing heterocyclic leaving groups with S-nucleophiles were studied. The methods of introduction of functionalized thiols, including thiol derivatives of 1,7- and 1,2-dicarba-closo-dodecaboranes, into the tetrazine ring were developed. It was established for the first time that, instead of replacement of a leaving group in the tetrazine ring, the attack of S-nucleophile at the unsubstituted carbon atom occurs in the case of imidazo[1,2-b][1,2,4,5]tetrazines to form previously unknown products of nucleophilic substitution of the hydrogen atom.

     

Synthesis and biological activity of 3-guanidino-6-R-imidazo[1,2-<Emphasis Type="Italic">b</Emphasis>]- and 6-guanidino-3-R-[1,2,4]triazolo[4,3-<Emphasis Type="Italic">b</Emphasis>][1,2,4,5]tetrazines

The reaction of azoloannulated [1,2,4,5]tetrazines with guanidine was studied. New 3-guanidinoimidazo[1,2-b]- and 6-guanidino[1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazines were synthesized using the nucleophilic substitution methodology. Compounds with high antibacterial and antiglycation activity were revealed.