Synthesis and Reaction Peculiarities of Phosphorylated Trifluoroethane Imines

Abstract

Convenient methods for C,N - mono- and biphosphorylated trifluoroethane imines have been developed. These are reactive synthons allowing important derivatives of aminophosphonic acids, fluorine- and phosphorus-containing heterocycles, vinylamides, etc. A rare example of a Perkov-type reaction involving trifluoromethyl group has been discovered.     

A new strategy for asymmetric synthesis of aminophosphonic acid derivatives: the first enantioselective catalytic reduction of C-phosphorylated imines

The first highly enantioselective catalytic reduction of 1-imino-2,2,2-trifluoroethylphosphonates and the synthesis of enantiomerically enriched biorelevant phosphonotrifluoroalanine is reported.     

Synthesis of sulfonimide-based dendrimers and dendrons possessing mixed 1 → 2 and 1 → 4 branching motifs

The synthesis of dendrimers and a chlorosulfo-dendron possessing a unique combination of 1?→?2 and 1?→?4 branching types is described. The procedure consists of a two-step preparation of 3,5-dinitrobenzene-1-sulfonyl chloride, which was used for the persulfonylation of p-toluidine and 4-(benzylthio)aniline. The obtained tetranitro compounds were reduced to the corresponding tetraamines. The latter were decorated with eight 4-toluene sulfonyl groups each to furnish the corresponding dendrimers. Oxidation of the dendrimer possessing a 4-(benzylthio)phenylene core with N-chlorosuccinimide resulted in the formation of a dendron with a sulfonyl chloride functionality at the focal point.     

N-Acyl-and N-Phosphorylpolyhalogenoalkyl-Imidolylphosphonates: Synthesis and Reactions

Abstract

Methods of synthesis of polyhalogenoalkylimidoyl phosphonates, the phosphorus analogs of a well-known and widely used acylimines of polyhalogenocarbonyl compounds, have been developed.     

Synthesis of (4-nitro-1H-indol-6-yl)- and (4-amino-1H-indol-6-yl)phosphonic acid derivatives

Chemistry of Heterocyclic Compounds - A convenient methodology for the synthesis of previously unreported (1H-indol-6-yl)phosphonic acid derivatives has been described. Reaction of...