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1.
A. V. Kolotaev L. I. Belen’kii A. S. Kononikhin M. M. Krayushkin 《Russian Chemical Bulletin》2006,55(5):892-897
Symmetrical and unsymmetrical α-diketones of the indole series were synthesized by the Friedel-Crafts reaction of 3-indolylglyoxyl
chlorides with heterocycles. A nonconventional reaction of N-unsubstituted diketones with hydrazine producing 3H-pyrazolo[3,4-c]quinoline derivatives was found.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 862–866, May, 2006. 相似文献
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L. I. Belen’kii A. V. Kolotaev V. Z. Shirinyan M. M. Krayushkin Yu. P. Strokach T. M. Valova Z. O. Golotyuk V. A. Barachevskii 《Chemistry of Heterocyclic Compounds》2005,41(1):86-92
The polar [4+2] cycloaddition reaction of 1,2-bis(2,5-dimethyl-3-thienyl)acetylene with thiobenzamide and certain aldehydes of the thiophene and furan series catalyzed by boron trifluoride etherate gives the corresponding 4-hetaryl-5,6-di(2,5-dimethyl-3-thienyl)-2-phenyl-4H-1,3-thiazines. The photochromic properties of the products have been studied.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 100–106, January, 2005. 相似文献
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It is shown for the first time that the Wurtz reaction can be realized by the action of an organic substance (triphenylphosphine) on an alkyl halide (perfluoroalkyl iodide) without the use of metals. It was found that when trying to prepare the bis(3,3′-aminophenyl)(fluoroalkyl)phosphine oxide by four-step synthesis, in the first stage of the reaction of perfluoro-1-iodohexane with triphenylphosphine does not proceed towards the formation of an intermediate quaternary phosphonium salt. Instead, the carbon chain of perfluoroalkyl iodide dimerizes to form perfluorododecane – Wurtz reaction product. We have proposed a new pathway for homocoupling of perfluoroalkylhalides into even-numbered perfluoroalkanes. 相似文献
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Balaev A. N. Osipov V. N. Okhmanovich K. A. Ruchko E. A. Kolotaev A. V. Khachatryan D. S. 《Russian Chemical Bulletin》2016,65(11):2766-2769
Russian Chemical Bulletin - New Boc-protected pentapeptide amides of the general formula Boc—Cys(Boc)—Phe—d-Trp—Lys(Boc)—Thr—NHR, which are analogs of the... 相似文献
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Zh. A. Krasnaya Yu. V. Smirnova A. S. Tatikolov A. V. Kolotaev 《Chemistry of Heterocyclic Compounds》2006,42(6):735-740
Bis-and tetrakis(ω-dimethylamino)-substituted cross-conjugated polyene α-diketones, containing two thiophene rings, were synthesized
from α-diketones of the thiophene series and β-dimethylaminoacrolein aminals and also 2-aza-3-dimethylaminoacrolein acetal.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 841–847, June, 2006. 相似文献
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Anton V. Kolotaev Karine R. Matevosyan Vasiliy N. Osipov Derenik S. Khachatryan 《Tetrahedron letters》2019,60(51):151315
Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction. 相似文献
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L. I. Belen'kii V. Z. Shirinyan G. P. Gromova A. V. Kolotaev Yu. A. Strelenko S. N. Tandura A. N. Shumskii M. M. Krayushkin 《Chemistry of Heterocyclic Compounds》2003,39(12):1570-1579
1,2-Dithienylethanediones were synthesized by modified acylation of thiophene and its homologs in the presence of aluminum chloride and pyridine. The bishydrazones of the products were converted into dithienylacetylenes by oxidation with atmospheric oxygen in pyridine in the presence of CuCl. 相似文献
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D.?S.?KhachatryanEmail author S.?K.?Belus V.?A.?Misyurin M.?A.?Baryshnikova A.?V.?Kolotaev K.?R.?Matevosyan 《Russian Chemical Bulletin》2017,66(6):1044-1058
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application. 相似文献