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Chathuranga S. L. Rathnamalala Selena Hernandez Dr. Melissa Y. Lucero Chelsea B. Swartchick Dr. Abdul Kalam Shaik Prof. Dr. Nathan I. Hammer Amanda K. East Prof. Dr. Steven R. Gwaltney Prof. Dr. Jefferson Chan Prof. Dr. Colleen N. Scott 《Angewandte Chemie (International ed. in English)》2023,62(13):e202214855
Shortwave infrared (SWIR) dyes are characterized by their ability to absorb light from 900 to 1400 nm, which is ideal for deep tissue imaging owing to minimized light scattering and interference from endogenous pigments. An approach to access such molecules is to tune the photophysical properties of known near-infrared dyes. Herein, we report the development of a series of easily accessible (three steps) SWIR xanthene dyes based on a dibenzazepine donor conjugated to thiophene ( SCR-1 ), thienothiophene ( SCR-2 ), or bithiophene ( SCR-3 ). We leverage the fact that SCR-1 undergoes a bathochromic shift when aggregated for in vivo studies by developing a ratiometric nanoparticle for NO ( rNP-NO ), which we employed to successfully visualize pathological levels of nitric oxide in a drug-induced liver injury model via deep tissue SWIR photoacoustic (PA) imaging. Our work demonstrates how easily this dye series can be utilized as a component in nanosensor designs for imaging studies. 相似文献
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Kiramage Chathuranga Asela Weerawardhana Niranjan Dodantenna Jong-Soo Lee 《Experimental & molecular medicine》2021,53(11):1647
A harmonized balance between positive and negative regulation of pattern recognition receptor (PRR)-initiated immune responses is required to achieve the most favorable outcome for the host. This balance is crucial because it must not only ensure activation of the first line of defense against viral infection but also prevent inappropriate immune activation, which results in autoimmune diseases. Recent studies have shown how signal transduction pathways initiated by PRRs are positively and negatively regulated by diverse modulators to maintain host immune homeostasis. However, viruses have developed strategies to subvert the host antiviral response and establish infection. Viruses have evolved numerous genes encoding immunomodulatory proteins that antagonize the host immune system. This review focuses on the current state of knowledge regarding key host factors that regulate innate immune signaling molecules upon viral infection and discusses evidence showing how specific viral proteins counteract antiviral responses via immunomodulatory strategies.Subject terms: Innate immunity, Post-translational modifications 相似文献
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A. D. K. Isuri Weeraratne Chathuranga C. Hewa-Rahinduwage Sunalee Gonawala Prof. Dr. Long Luo Prof. Dr. Cláudio N. Verani 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(62):14048-14053
The use of metallosurfactants to prevent pitting corrosion of aluminum surfaces is discussed based on the behavior of the metallosurfactants [ZnII(LN2O2)H2O] ( 1 ) and [GaIII(LN2O3)] ( 2 ). These species were deposited as multilayer Langmuir–Blodgett films and characterized by IR reflection absorption spectroscopy and UV/Vis spectroscopy. Scanning electron microscopy images, potentiodynamic polarization experiments, and electrochemical impedance spectroscopy were used to assess corrosion mitigation. Both metallosurfactants demonstrate superior anticorrosion activity due to the presence of redox-inactive 3d10 metal ions that enhance the structural resistance of the ordered molecular films and limit chloride mobility and electron transfer. 相似文献
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