Comments on "Earphones in Audiometry" [Zwislocki et al., J. Acoust. Soc. Am. 83, 1688-1689 (1988)

The Zwislocki et al. ["Earphones in Audiometry," J. Acoust. Soc. Am. 83, 1688-1689 (1988)] Letter to the Editor states that insert earphones have some unresolved technical problems, such as limited frequency response, limited dynamic range and power handling capability, intersubject variability, and hygiene safety. In evaluating circumaural earphones, Zwislocki et al. say that the lack of a standard coupler disqualifies them for audiometry. Since this letter carries the weight of a CHABA committee recommendation, these issues are commented on herein. Section I was written primarily by Mead Killion and Sec. II primarily by Edgar Villchur. For brevity throughout, the authors of the Zwislocki et al. letter will be referred to as "the authors."     

Comparison of the noise attenuation of three audiometric earphones, with additional data on masking near threshold

The noise-excluding properties of a standard supra-aural audiometric earphone, a widely used circumaural-supra-aural combination, and an insert earphone sealed to the ear with a vinyl foam eartip were measured in a diffuse-field room complying with ANSI S12.6-1984. Data on attenuation were obtained monaurally with the nontest ear plugged and muffed. Results for the supra-aural earphones generally agreed well with previously reported measurements. A broadband masking noise was used to directly test the ANSI S3.1-1977 permissible background noise levels for measuring to audiometric zero using standard audiometric earphones. This "ANSI noise" raised the average thresholds of 15 normal-hearing test subjects by 3 to 5 dB at the octave frequencies from 500 to 4000 Hz. With a noise conforming to the less stringent OSHA-1983 regulation, average thresholds were elevated 9 to 17 dB. An "ENT office noise" with an overall sound level of 54 dBA raised average thresholds even further, by as much as 29 dB at 500 Hz. Use of the circumaural system in the office noise limited the threshold elevation to 11, 5, 2, and 0 dB at the four octave frequencies tested. With the fully ("deeply") inserted foam eartips, the threshold elevation in the simulated office noise was 2 dB or less at all test frequencies. Actual threshold elevations agreed closely with predictions based on a critical ratio calculation utilizing measured sound field noise levels and measured earphone attenuation values.     

Screening of octanol-water partition coefficients for pharmaceuticals by pressure-assisted microemulsion electrokinetic chromatography

A rapid screening assay for the determination of octanol-water partition coefficients (log P(OW)) of pharmaceuticals was developed by using pressure-assisted microemulsion electrokinetic chromatography (MEEKC). The microemulsion system contains 50 mM sodium dodecyl sulfate, 0.87 M l-butanol, 82 mM heptane, and 50 mM borate-phosphate (2:3) at pH 10. Ten standard compounds with known log P(OW) values from -0.26 to 4.88 were used for constructing the calibration curve of log P(OW) against the MEEKC retention factor, log k. The log P(OW) values of the compounds were calculated based on the log k values measured by MEEKC and the slope and intercept of the calibration curve. For 13 literature and 32 Roche compounds, about 90% of the log P(OW) values measured by MEEKC are within 0.5 log units of the values from the literature and potentiometric titration. The throughput is about 2 samples/h using +20 kV voltage plus 5 mbar air pressure for separation. This MEEKC method is applicable for log P(OW) screening of weakly basic, weakly acidic, and neutral pharmaceuticals with log P(OW) = 0-5 and pKa < or = 10.     

Synthesis and characterization of physically crosslinked N‐vinylcaprolactam,acrylic acid,methacrylic acid,and N,N‐dimethylacrylamide hydrogels

Physically crosslinked hydrogels based on N‐vinylcaprolactam/acrylic acid and N‐vinylcaprolactam/methacrylic acid were prepared via free radical polymerization. These temperature responsive hydrogels were characterized in terms of glass transition, phase separation temperature, potentiometric titration and swelling properties. Results showed that phase transition temperature was dependent on the pH value of the solution; increasing pH led to higher lower critical solution temperature (LCST) values which was related to the dissociative behaviors of the carboxylic group of MAc in the buffered solutions. Additionally, with the incorporation of N,N‐dimethylacrylamide into the system, cloud point measurements and MDSC showed an increased in the LCST. This increase was based on hydrophilicity, the hydrophilic–hydrophobic balance was disturbed, and consequently, the LCST behavior was shifted. The pKa of the copolymers ranged between 5.6 and 6.5, while for the terpolymers pKa ranged between 5.3 and 6. At high pH (>10), the ? COOH group is deprotonated and negatively charged (? COO^?), while at low pH (1–3) the carboxylic group remains protonated which results in hydrogen bonding between the hydroxyl groups (from NaOH) and the excess of HCl. These results correlate with swelling studies where above the pKa value the hydrogels dissolved rapidly compared to below pKa they did not dissolve at all. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013 , 51, 1555–1564     

Mechanical and biodegradation performance of short natural fibre polyhydroxybutyrate composites

The work outlined in this paper describes the evaluation of polyhydroxybutyrate (PHB) based natural fibre composites via an extrusion – injection moulding process. Virgin PHB was compounded with two different naturally occuring plant fibres, hemp and jute, and a third, regenerated cellulose fibre, lyocell. Composite materials containing 10–30 wt% of each type of fibre were obtained by twin screw extrusion and the resultant material was injection moulded to produce tensile samples suitable for mechanical characterisation. Mechanical properties were determined using tensile, impact and flexural testing. Melt flow index and water absorption studies were also carried out on the biocomposite materials, and Fourier transform infrared spectroscopy was used to examine the bonding between the polymer and each fibre type. The rate of biodegradation was also observed by placing composite samples in compost and measuring weight loss weekly. The biocomposites produced using this method were shown to have increased rates of biodegradation whilst exhibiting significantly improved flexural properties.