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Mehiaoui Nawel Kibou Zahira Berrichi Amina Bachir Redouane Choukchou-Braham Noureddine 《Research on Chemical Intermediates》2020,46(12):5263-5280
Research on Chemical Intermediates - The current work described a new and highly selective method for the synthesis of substituted 3-cyano-2-pyridones scaffolds using gold-cobalt supported on TiO2... 相似文献
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Nouali Fatiha Kibou Zahira Boukoussa Bouhadjar Choukchou-Braham Noureddine Bengueddach Abdelkader Villemin Didier Hamacha Rachida 《Research on Chemical Intermediates》2020,46(6):3179-3191
Research on Chemical Intermediates - An efficient and green procedure for the synthesis of 2-aminopyridines derivatives via four-component reaction of acetophenone, malononitrile, triethoxymethane... 相似文献
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Bouhadjar Boukoussa Zahira Kibou Zakaria Abid Rachida Ouargli Noureddine Choukchou-Braham Didier Villemin Abdelkader Bengueddach Rachida Hamacha 《Chemical Papers》2018,72(2):289-299
Mesoporous silica Si-MCM-41 was prepared by hydrothermal method using TEOS and CTAB as the source of silica and structuring agent, respectively. The surface of the as-synthesized material was treated using HCl/ETOH solvent to remove the CTA surfactant instead of using the calcination. Characterization of the catalysts was performed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen sorption at 77 K, scanning and transmission electronic microscopy (SEM, TEM), and thermogravimetric analysis TGA. The catalytic properties of the prepared materials in the condensation of acetophenone with ethyl cyanoacetate were studied. The effects of the catalyst type, Si/Al ratio, reaction kinetics, and reaction temperature were also investigated to find an optimal parameter. The results show that an interesting yield was obtained (about 96%) in a short reaction time; it is found that the yields of products depend not only on the amount of surfactant inside the mesopores but also on the Si/Al ratio. The catalyst reuse shows that this catalyst can be used up to five cycles, and at temperatures higher than 50 °C, the yield of products decreases due to the slight destruction of the catalyst as confirmed by the XRD analysis. Based on the results obtained, a possible mechanism of the condensation reaction of acetophenone was proposed. 相似文献
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Mehiaoui Nawel Kibou Zahira Gallavardin Thibault Leleu Stéphane Franck Xavier Mendes Ricardo F. Paz Filipe A. Almeida Silva Artur M. S. Choukchou-Braham Noureddine 《Research on Chemical Intermediates》2021,47(4):1331-1348
Research on Chemical Intermediates - Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push–pull dienes as key building blocks.... 相似文献
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Zahira Kibou Nadia Aissaoui Ismail Daoud Julio A. Seijas María Pilar Vzquez-Tato Nihel Klouche Khelil Noureddine Choukchou-Braham 《Molecules (Basel, Switzerland)》2022,27(11)
A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives. Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions. Methods: A range of spectroscopic techniques was used to determine and confirm the chemical structures (FTIR, 1H NMR, 13C NMR). The antimicrobial potency of synthesized compounds (2a–d) was tested using disk diffusion assays, and the Minimum Inhibitory Concentration (MIC) for the active compounds was determined against a panel of microorganisms, including Gram-positive and Gram-negative bacteria and yeasts. Moreover, a docking analysis was conducted by Molecular Operating Environment (MOE) software to provide supplementary information about the potential, as well as an ADME-T prediction to describe the pharmacokinetic properties of the best compound and its toxicity. Results: The results of the antimicrobial activity indicated that compound 2c showed the highest activity against Gram-positive bacteria, particularly S. aureus and B. subtilis whose MIC values were 0.039 ± 0.000 µg·mL−1. The results of the theoretical study of compound 2c were in line with the experimental data and exhibited excellent antibacterial potential. Conclusions: On the basis of the obtained results, compound 2c can be used as an antibacterial agent model with high antibacterial potency. 相似文献
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