New tetrazoloquinolinyl methoxyphenyl-4-thiazolidinones: synthesis and antihyperglycemic evaluation

Research on Chemical Intermediates - We report synthesis and in vivo antihyperglycemic evaluation of new 3-substituted...     

Diisopropylethylammonium acetate (DIPEAc): An efficient and recyclable catalyst for the rapid synthesis of 5-substituted-1H-tetrazoles

A simple and efficient protocol developed for the synthesis of 5-substituted 1H-tetrazole derivatives through [2+3] cycloaddition reaction between benzonitriles and sodium azide using diisopropylethylammonium acetate as a recyclable reaction medium is described. The reactions proceed well at 80?°C and provide the corresponding tetrazoles in good to excellent yields (up to 94% yield). Developed method has notable advantages, such as simple and mild conditions, easy workup, reusability with consistent catalytic activity, and safer alternative to hazardous, corrosive conventional Lewis acid catalysts.     

Detection of amitraz,a formamidine-based pesticide using chromogenic spray reagent by thin-layer chromatography

JPC – Journal of Planar Chromatography – Modern TLC - In the present study, we developed a simple, sensitive and selective thin-layer chromatographic method for the detection and...     

Spermicidal activity of the hexane extract of Piper longum: an in vitro study

This study was carried out to assess the spermicidal action of hexane extract from the fruits of Piper longum Linn. The sperm immobilisation studies showed that 20 mg/mL of hexane extract was able to immobilise sperms completely within 20 s. The sperm revival test revealed that the effects were spermicidal as sperm immobilisation effect was irreversible. There was also a significant reduction in sperm viability in the treated group in comparison to the control. The hypo-osmotic swelling of these sperms was significantly reduced, indicating that the hexane extract may probably cause injury to the sperm plasma membrane. Hence, this study showed that the hexane extract of P. longum possesses potential contraceptive spermicidal activity in vitro.     

Efficient sonochemical protocol for the facile synthesis of dipyrimido-dihydropyridine and pyrimido[4,5-d]pyrimidines in aqueous β-cyclodextrin

An economical and efficient synthesis of dipyrimido-dihydropyridines and pyrimido[4,5-d]pyrimidines is described using greener and recyclable β-cyclodextrin as a supramolecular catalyst in aqueous medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst, and excellent yields of the products. The highly functional group tolerance and shorter reaction times make this method suitable for the synthesis of dihydropyridine and pyrimido[4,5-d]pyrimidine derivatives with a wide substitution pattern.