排序方式: 共有9条查询结果,搜索用时 15 毫秒
1
1.
Shestakova Tatyana S. Deev Sergey L. Khalymbadzha Igor А. Rusinov Vladimir L. Paramonov Alexander S. Arseniev Alexander S. Shenkarev Zakhar O. Charushin Valery N. Chupakhin Oleg N. 《Chemistry of Heterocyclic Compounds》2021,57(4):479-482
Chemistry of Heterocyclic Compounds - Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C... 相似文献
2.
3.
Vyacheslav Ya. Sosnovskikh Igor A. Khalymbadzha Roman A. Irgashev Pavel A. Slepukhin 《Tetrahedron》2008,64(44):10172-10180
3-(Polyfluoroacyl)chromones undergo heterodiene cycloaddition to 3,4-dihydro-2H-pyran, 2,3-dihydrofuran and ethyl vinyl ether under mild conditions, producing novel fused pyrans with high stereoselectivity and in good yields. Some of these pyrans were transformed into 2-RF-containing pyridines on treatment with ammonium acetate in ethanol. 相似文献
4.
I. A. Khalymbadzha T. S. Shestakova S. L. Deev V. L. Rusinov O. N. Chupakhin Z. O. Shenkarev A. S. Arseniev 《Russian Chemical Bulletin》2013,62(2):521-528
A new method was developed for the investigation of an azido-tetrazole equilibrium based on using a complex analysis of 13C-15N and 1H-15N spin-spin coupling constants. The use of this approach became possible due to the selective inclusion of 15N isotopes into the structures of 2-azidopyrimidines and their cyclic analogs tetrazolo[1,5-a]pyrimidines. 相似文献
5.
Slepukhin P. A. Fatykhov R. F. Sharapov A. D. Valieva M. I. Starnovskaya E. S. Khalymbadzha I. A. Kopchuk D. S. Zyryanov G. V. Chupakhin O. N. 《Russian Journal of General Chemistry》2022,92(7):1285-1289
Russian Journal of General Chemistry - The molecular and crystal structures of 8-(3,6-diphenylpyridin-2-yl)-5,7-dimethoxy-4-phenyl-2H-chromen-2-one,... 相似文献
6.
V. Ya. Sosnovskikh R. A. Irgashev I. A. Khalymbadzha 《Russian Chemical Bulletin》2007,56(8):1608-1611
Reaction of 3-(trifluoroacetyl)chromones with ethylenediamine and o-phenylenediamine depending on the nature of substituents and the reaction conditions afforded either mono-adducts, 3-[(2-aminoethyl)aminomethylidene]-and
3-[(2-aminophenyl)aminomethylidene]-2-hydroxy-2-(trifluoromethyl)chroman-4-ones, or bis-adducts, N,N′-ethylenebis-and N,N′-o-phenylenebis[3-aminomethylidene-2-hydroxy-2-(trifluoromethyl)chroman-4-ones].
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1548–1551, August, 2007. 相似文献
7.
8.
T. S. Shestakova I. A. Khalymbadzha S. L. Deev O. S. Eltsov V. L. Rusinov Z. O. Shenkarev A. S. Arseniev O. N. Chupakhin 《Russian Chemical Bulletin》2011,60(4):729-732
Selective methods for the incorporation of stable isotopes 15N and 2H into the structure of antiviral medicine “triazavirine” 1 were developed. The synthesized isotopically modified “triazavirine” 1–
2
H
3
,
15
N
3
contained the labeled atoms in both the azole and the azine rings. 13C and 15N NMR spectra of the isotope-containing sample 1–
2
H
3
,
15
N
3
were thoroughly analyzed. 相似文献
9.
Igor A. Khalymbadzha Tatyana S. Shestakova Julia O. Subbotina Oleg S. Eltsov Alexandra A. Musikhina Vladimir L. Rusinov Oleg N. Chupakhin Inna L. Karpenko Maxim V. Jasko Marina K. Kukhanova Sergey L. Deev 《Tetrahedron》2014
New acyclovir analogues were obtained by reaction of 1,2,4-triazolo[1,5-a]pyrimidin-7-ones 4a–i with (2-acetoxyethoxy)methyl acetate 5 in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) as catalyst (Vorbrüggen procedure). Coupling between compounds 4a–f and 5 led to a mixture of N3- and N4-isomers 6 and 7, respectively. On the contrary, the reaction of compounds 4g–i with 5 proceeded selectively with formation of N3-isomers only. It was found that the ratio of 6a–f and 7a–f depends on the presence or the absence of N,O-bis(trimethylsilyl)acetamide (BSA). Glycosylated products 6a–f and 7a–f underwent reversible isomerization under TMSOTf treatment. The ratio of glycosylated products of the coupling reaction between 4 and 5 was thermodynamically controlled. A similar reaction occurred if ZnCl2 was chosen as a catalyst, although lower yields of the acyclic analogues of nucleosides were observed. The glycosylation of other purines (adenine and guanine) can be achieved via the non-BSA modification of the Vorbrüggen procedure. 相似文献
1